Table 4.
k-Fold cross validations for the Aβ PET case-control dataset using two different pT thresholds and methods to model APOE
| Model Description | pT | k-fold | AUC |
|---|---|---|---|
| APOE4 | - | k1 | 0.727 |
| k2 | 0.666 | ||
| k3 | 0.685 | ||
| k4 | 0.705 | ||
| k5 | 0.644 | ||
| mean (SD) | 0.685 (± 0.0326) | ||
| APOE4 + APOE2 | - | k1 | 0.775 |
| k2 | 0.757 | ||
| k3 | 0.714 | ||
| k4 | 0.614 | ||
| k5 | 0.738 | ||
| mean (SD) | 0.719 (± 0.0634) | ||
| Aβ.PRS.full | 0.1 | k1 | 0.808 |
| k2 | 0.583 | ||
| k3 | 0.578 | ||
| k4 | 0.489 | ||
| k5 | 0.519 | ||
| mean (SD) | 0.595 (± 0.125) | ||
| 1.0 × 10− 5 | k1 | 0.508 | |
| k2 | 0.722 | ||
| k3 | 0.604 | ||
| k4 | 0.790 | ||
| k5 | 0.531 | ||
| mean (SD) | 0.631 (± 0.122) | ||
| Aβ.PRS.no.APOE | 0.1 | k1 | 0.423 |
| k2 | 0.455 | ||
| k3 | 0.668 | ||
| k4 | 0.790 | ||
| k5 | 0.719 | ||
| mean (SD) | 0.611 (± 0.166) | ||
| 1.0 × 10− 5 | k1 | 0.436 | |
| k2 | 0.428 | ||
| k3 | 0.390 | ||
| k4 | 0.477 | ||
| k5 | 0.388 | ||
| mean (SD) | 0.424 (± 0.0369) | ||
| Aβ.PRS.1 | 0.1 | k1 | 0.850 |
| k2 | 0.781 | ||
| k3 | 0.765 | ||
| k4 | 0.494 | ||
| k5 | 0.713 | ||
| mean (SD) | 0.720 (± 0.136) | ||
| 1.0 × 10− 5 | k1 | 0.866 | |
| k2 | 0.789 | ||
| k3 | 0.626 | ||
| k4 | 0.685 | ||
| k5 | 0.625 | ||
| mean (SD) | 0.718 (± 0.106) | ||
| Aβ.PRS.2 | 0.1 | k1 | 0.711 |
| k2 | 0.856 | ||
| k3 | 0.802 | ||
| k4 | 0.665 | ||
| k5 | 0.750 | ||
| mean (SD) | 0.757 (± 0.0749) | ||
| 1.0 × 10− 5 | k1 | 0.668 | |
| k2 | 0.639 | ||
| k3 | 0.850 | ||
| k4 | 0.710 | ||
| k5 | 0.806 | ||
| mean (SD) | 0.735 (± 0.0903) |