Table 5.
External validation for the Aβ PET case-control dataset using two different pT thresholds and methods to model APOE
| Model Description | pT | AUC | 95% CI | Sensitivity | Specificity | Accuracy |
|---|---|---|---|---|---|---|
| Aβ.PRS.full | 0.1 | 0.617 | 0.481–0.753 | 0.188 | 0.959 | 0.654 |
| 1.0 × 10− 5 | 0.678 | 0.554–0.802 | 0.281 | 0.898 | 0.654 | |
| Aβ.PRS.no.APOE | 0.1 | 0.594 | 0.459–0.729 | 0.125 | 0.959 | 0.630 |
| 1.0 × 10− 5 | 0.477 | 0.347–0.607 | 0 | 1 | 0.605 | |
| Aβ.PRS.1 | 0.1 | 0.698 | 0.571–0.825 | 0.594 | 0.714 | 0.667 |
| 1.0 × 10− 5 | 0.698 | 0.577–0.820 | 0.625 | 0.694 | 0.667 | |
| Aβ.PRS.2 | 0.1 | 0.703 | 0.578–0.828 | 0.594 | 0.714 | 0.667 |
| 1.0 × 10− 5 | 0.703 | 0.583–0.824 | 0.625 | 0.694 | 0.667 |