Table 3.

Study group treatment details for phase I trials of centhaquine

Study groups	Treatment
Single ascending dose
Cohort I	Centhaquine 0.005 mg/kg (n = 3) or placebo (n = 1)
Cohort II	Centhaquine 0.01 mg/kg (n = 3) or placebo (n = 1)
Cohort III	Centhaquine 0.05 mg/kg (n = 3) or placebo (n = 1)
Cohort IVa	Centhaquine 0.1 mg/kg (n = 3) or placebo (n = 1)
Multiple ascending dose
Cohort V	Centhaquine 0.033 mg/kg (n = 3) or placebo (n = 1) every 8 h for 2 days
Cohort VI	Centhaquine 0.067 mg/kg (n = 3) or placebo (n = 1) every 8 h for 2 days

h hours

^aAn intermediate dose of centhaquine 0.10 mg/kg (n = 3) was used after noticing an adverse event at 0.15 mg/kg (n = 1)