Table 1: Honorable Mention Studies.

CT: computed tomography; ECG: electrocardiogram; HFpEF: heart failure with preserved ejection fraction; LDL: low density lipoprotein

Article	Outcome	Sample Size	Median Age (years)
Primary Prevention and Screening
Association of Statin Use With Disability-Free Survival and Cardiovascular Disease Among Healthy Older Adults. J Am Coll Cardiol. 2020 Jul 7;76(1):17–27.	In a sub-study of patients enrolled in ASPREE (community- dwelling adults >70 years of age), statin use did not prolong disability-free survival over 4.7 years of follow-up.	5,629	74.2
Screening for Atrial Fibrillation in Older Adults at Primary Care Visits: VITAL-AF Randomized Controlled Trial. Circulation. 2022 Mar 29;145(13):946–954.	16 primary care clinics were randomized to use a handheld single-lead ECG for patients >65 years of age without known atrial fibrillation. There was no difference in the rates of new atrial fibrillation diagnoses compared to usual care.	30,715	74
CT or Invasive Coronary Angiography in Stable Chest Pain. N Engl J Med. 2022 Apr 28;386(17):1591–1602.	Patients with stable chest pain and intermediate pretest probability were randomized to coronary CT vs. invasive angiography. The risk of major adverse cardiovascular events was similar in both groups but procedure-related complications were lower in the CT group.	3,561	60.9
Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial. Eur Heart J. 2022 Jun 1;43(21):2054–2061.	Individuals aged 60–77 years were randomized to a 2-year multi-domain intervention. Using national health registries over 7.4 years, total cardiovascular events were lower.	1,259	69.4
Secondary Prevention and Management
Cognition After Lowering LDL-Cholesterol With Evolocumab. J Am Coll Cardiol. 2020 May 12;75(18):2283– 2293.	All patients enrolled in FOURIER completed a 23-item survey on memory and executive function. The addition of evolocumab had no impact on patient-reported cognition after 2.2 years, even among those with LDL < 20 mg/dL.	22,655	62.5
Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. N Engl J Med. 2020 Oct 1;383(14):1305–1316.	Patients with atrial fibrillation diagnosed <1 year before enrollment randomized to early rhythm control had lower risk of adverse cardiovascular events vs. a rate control strategy.	2,789	70.3
Effect of an Emergency Department Care Bundle on 30-Day Hospital Discharge and Survival Among Elderly Patients With Acute Heart Failure: The ELISABETH Randomized Clinical Trial. JAMA. 2020 Nov 17;324(19):1948–1956.	In a cluster randomized trial of patients >75 years presenting with acute heart failure to 15 French emergency departments, a care bundle compared to usual care did not result in a difference in days alive and out of the hospital at 30 days.	503	87
Influenza Vaccination After Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. Circulation. 2021 Nov 2;144(18):1476–1484.	Influenza vaccination shortly after myocardial infarction or high-risk stable coronary heart disease reduced a 12-month cardiovascular composite endpoint.	2,571	59.8
Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2021 Nov 23;78(21):2042–2056.	Based on cardiopulmonary exercise testing, beta-blocker withdrawal improved maximal functional capacity in patients with HFpEF and chronotropic incompetence.	52	72.6
Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results From the CABANA Trial. Circulation. 2022 Mar 15;145(11):796–804.	Stratification of patients in CABANA to <65, 65-to-74, and >75 years of age illustrated variations in clinical outcomes for catheter ablation. The largest relative and absolute benefits were in younger patients with no benefit in patients >75 years.	2,204	68