Table 5.
Detection performance of different screening strategies for Down syndrome.
| Strategy 1 | Strategy 2 | Strategy 3 | Strategy 4 | Strategy 5 | Strategy 6 | Strategy 7 | Strategy 8 | |
|---|---|---|---|---|---|---|---|---|
| True positive | 163 | 83 | 130 | 129 | 128 | 135 | 134 | 142 |
| False positive | 35 | 11,218 | 33,860 | 11,245 | 47 | 7,313 | 63 | 0 |
| True negative | 140,062 | 128,879 | 106,237 | 128,852 | 140,050 | 132,784 | 140,034 | 140,092 |
| False negative | 5 | 85 | 38 | 39 | 40 | 33 | 34 | 31 |
| Prenatal diagnosis | 198 | 11,031 | 33,990 | 11,374 | 175 | 7,448 | 197 | 43,573 |
| Termination of pregnancy | 163 | 83 | 130 | 129 | 128 | 135 | 134 | 142 |
| Sensitivity (95% CI) |
97.02% (94.45–99.59%) |
49.40% (41.85–56.97%) |
77.38% (71.06–83.71%) |
76.79% (70.40–83.17%) |
76.19% (69.75–82.63%) |
80.36% (74.35–86.37%) |
79.76% (73.69–85.84%) |
82.08% (76.37–87.80%) |
| Specificity (95% CI) |
99.98% (99.97–99.98%) |
91.99% (91.85–92.14%) |
75.83% (75.61–76.06%) |
91.97% (91.83–92.12%) |
99.97% (99.96–99.98%) |
94.78% (94.66–94.90%) |
99.96% (99.94–99.97%) |
100.00% (100.00–100.00%) |
Prenatal diagnosis: the sum of true positives and false positives.