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. 2025 May 9;5:1589903. doi: 10.3389/fnume.2025.1589903

Table 1.

Characteristics of the studies included in the systematic review.

Authors Year Country Journal Number of patients Sex Age Type of lymphoma FAPI tracer SUVmax FAPI SUVmax FDG
Wang et al. 2025 China Clin Nucl Med 1 F 56 MALT: primary pulmonary MALT 68Ga-FAPI 8.1 3.7
Hirmas et al. 2024 Germany J Nucl Med 10 NR NR NR 68Ga-FAPI NR NR
Ran et al. 2024 China Clin Nucl Med 1 M 22 T-cell lymphoma: primary peripheral T-cell lymphoma of the skeletal muscles with brain involvement 18 F-FAPI-42 Muscles: 4.9
Brain lesion: 0.9
Muscles: 21.3
Brain lesion: 8.9
Liu et al. 2024 China Clin Nucl Med 1 F 44 T-cell lymphoma: Mycosis fungoides-type
cutaneous T-cell lymphoma
18 F-FAPI-42 Skin: 11.3
Inguinal lymph nodes: 3.8
Skin: 7.7
Inguinal lymph nodes: 5.2
Chen et al. 2023 China J Nucl Med 186 91 M; 95 F 52 (median) HL 24 (12.9%)
Non-Hodgkin lymphoma 162 (87.1%)
DLBCL 80 (43.0%)
Primary mediastinal large B-cell lymphoma 4 (2.2%)
Mantle cell lymphoma 5 (2.7%)
Burkitt lymphoma 2 (1.1%)
Lymphoblastic leukemia/lymphoma 6 (3.2%)
PTCL 18 (9.7%)
Extranodal NK/T-cell lymphoma 6 (3.2%)
FL 31 (16.7%)
MALT 8 (4.3%)
Chronic lymphocytic leukemia/small
lymphocytic lymphoma
68Ga-FAPI Nodal lesions:
HL: 8.6
NHL 7.3
Extranodal lesions:
HL: 7.9
NHL: 7.1
Nodal lesions:
HL: 11.6
NHL: 10.5
Extranodal lesions
HL: 10.1
NHL: 11
Lu et al. 2023 China Clin Nucl Med 1 M 73 DLBLC 18 F-FAPI negative 18.9
Wu et al. 2022 China Diagnostics (Basel) 1 M 82 T-Cell
Lymphoma: Angioimmunoblastic T-Cell
Lymphoma
68Ga-FAPI 1.6 7.6
Jin et al. 2022 China J Nucl Med 73 (11 HL, 63 NHL) 36 F;
37 M
51.6 ± 14.2 HL, NHL 68Ga-FAPI 9.46 N/A
Pang et al. 2022 China Clin Nucl Med 1 M 76 MALT: primary hepatic extranodal marginal zone lymphoma of mucosa-associated
lymphoid tissue
68Ga-FAPI 1.56
higher TBR than 18F-FDG (1.6 vs. 0.7).
2.8
Kou et al. 2022 China Clin Nucl Med 1 M MALT: mucosa-associated lymphoid tissue lymphoma with secondary liver involvement. Al18F-NOTA-FAPI-04 Hepatic lesion: 4.9 Hepatic lesion: no abnormal uptake
Chen et al. 2022 China Clin Nucl Med 1 M 67 Follicular lymphoma 68Ga-FAPI-04 Stomach: 15.1
Lymph nodes: 5.8
Stomach: 6
Lymph nodes: 10
Yang et al. 2022 China J Nucl Cardiol 1 F 32 DLBLC: mediastinal lymphoma 68Ga-FAPI 13 N/A
Yang et al. 2021 China Endocrine 1 F 60 DLBLC: thyroid lymphoma 68Ga-FAPI 8.6 N/A
Zhang 2021 China Clin Nucl Med 1 F 67 DLBLC: primary central nervous system lymphoma 68Ga-FAPI CNS lesion: 3.1 CNS lesion: 9.6
Wang 2020 China Clin Nucl Med 1 F 55 DLBLC: primary gastric lymphoma 68Ga-NOTA-FAPI-04 Stomach: 5
Lymph nodes: 1.4
Stomach: 2.9
Lymph nodes: 2

NR, not reported; MALT, mucosa-associated lymphoid tissue; DLBLC, diffuse large B-cell lymphoma.