Table 2.

Inhibitory activities of compounds 4a-t against CDK9 and CDK12

Compound	IC50 (μM)
	CDK9	CDK12
4a	0.396 ± 0.017	0.295 ± 0.011
4b	1.15 ± 0.05	0.566 ± 0.022
4c	0.041 ± 0.002	0.14 ± 0.005
4 d	0.782 ± 0.034	1.329 ± 0.052
4e	0.409 ± 0.018	0.425 ± 0.017
4f	0.762 ± 0.033	1.143 ± 0.044
4 g	0.114 ± 0.005	0.071 ± 0.003
4 h	0.05 ± 0.002	0.153 ± 0.006
4i	1.088 ± 0.047	0.365 ± 0.014
4j	0.055 ± 0.002	0.104 ± 0.004
4k	5.468 ± 0.236	1.211 ± 0.047
4 l	1.673 ± 0.072	0.899 ± 0.035
4 m	0.04 ± 0.002	0.06 ± 0.002
4n	0.392 ± 0.017	0.179 ± 0.007
4o	1.045 ± 0.045	1.876 ± 0.073
4p	0.153 ± 0.007	0.664 ± 0.026
4q	0.057 ± 0.002	0.074 ± 0.003
4r	0.242 ± 0.01	0.104 ± 0.001
4 s	0.408 ± 0.018	0.189 ± 0.007
4 t	0.121 ± 0.005	0.533 ± 0.021
Dinaciclib	0.032 ± 0.001	% 1.% 2 ± 0.002