Table 4.

Parameters for the model.

Parameters	Descriptions	Values	References
	Rate of production of ECM by F	21.71	est.
	Rate of recruitment of		est.
	Rate of -induced transition		est.
	Rate of -induced transition		est.
	Rate of -induced transition		est.
	Rate of transition		est.
	Rate of proliferation of F	0.15	est.
	Rate of transition	0.015	est.
	Rate of maturation of E by EPC		est.
	Recruitment rate of P	g/	est.
	Rate of production of P by F		est.
	Rate of production of		est.
	Rate of production of by F		est.
	Rate of production of by		est.
	-factor of -production by F	0.1	est.
	Rate of production of V by	3.17	est.
	Rate of production of V by F	3.17	40,41est.
	Rate of production of V by	31.7	40,41est.
	Rate of production of by		66est.
	Rate of circulation of oxygen		est.
	Rate of Q-enhanced proliferation of F	0.2 d	est.
	Rate of consumption of oxygen	0.3 /g	est.
	Factor of internal isotropic medium	0.19	est.
	Chemotactic coefficient of P	1000 /gd	81est.
	Chemotactic coefficient of V	1000 /gd	81est.
	Fraction of effect of on production of by F	0.1	est.
	Coefficient of maturation of E by V	1	est.
	Half-saturation of	g/	70est.
	Half-saturation of	g/	69est.
	Half-saturation of P	g/	71est.
	Half-saturation of	g/	72est.
	Half-saturation of V	g/	9est.
	Healthy state of ECM	0.04 g/	61est.
	Threshold of pressure of ECM	0.008 g/	61est.
	Carrying capacity of ECM	0.044 g/	61est.
	Recruitment rate of	g/	est.
	Oxygen concentration	g/	82,83est.
	Oxygen concentration in extreme hypoxia	g/	82,83est.
	Steady state in health of	g/	63est.
	Steady state in health of	g/	63est.
	Steady state in health of F	g/	64,65est.
	Steady state in health of	g/	66est.
	Steady state in health of E	g/	67,68est.
	Degradation rate of ECM	0.37	36
	Degradation rate of PDGF	33	84est.
	Degradation rate of TNF-	216.6	76est.
	Degradation rate of TGF-	495.1	85est.
	Degradation rate of VEGF	16.5	86est.
	Degradation rate of oxygen		87est.
	Death rate of	0.033	78est.
	Death rate of	0.099	78est.
	Death rate of endothelial cells	0.045	80est.
	Death rate of F	0.02	88est.
	Death rate of	0.025	est.
	Death rate of	1.073	73est.
	Depletion rate of P by F		est.
	Depletion rate of P by M		est.
	Depletion rate of E by V	19.8	est.
	Depletion rate of by w		est.
	Death rate of F by w		est.
	Rate of Q-enhanced secretion of by F	d	est.
	Rate of elimination of by Q		est.
	Diffusion coefficient of		89est.
	Diffusion coefficient of		89est.
	Diffusion coefficient of E		89est.
	Diffusion coefficient of F		89est.
	Diffusion coefficient of		89est.
	Diffusion coefficient of P		90est.
	Diffusion coefficient of		91est.
	Diffusion coefficient of		91est.
	Diffusion coefficient of V		92est.
	Diffusion coefficient of w	2	93est.
	Diabetic effect of oxygen flow blockade	10	This work
	Diabetic effect of blockade	2	This work
	Diabetic effect of blockade	50 d	This work