Table 2.

The binding energy of compound and core targets (kcal/mol)

Target	Target	Compound	Affinity
	(PDB ID)		(kcal/mol)
EGFR	6LUD	Ferulic acid	− 5.8
		Caffeic Acid	− 5.9
		Paclitaxel	− 9.2
		Carboplatin	− 4.8
		Carboplatin Paclitaxel	− 9.2
TP53	4RG2	Ferulic acid	− 7.2
		Caffeic Acid	− 6.9
		Paclitaxel	− 7.2
		Carboplatin	− 5.6
		Carboplatin Paclitaxel	− 7.9
CTNNB1	7AFW	Ferulic acid	− 5.2
		Caffeic Acid	− 5.4
		Paclitaxel	− 7.4
		Carboplatin	− 4.9
		Carboplatin Paclitaxel	− 7.4
CCND1	2W96	Ferulic acid	− 6.4
		Caffeic Acid	− 6.2
		Paclitaxel	− 8.4
		Carboplatin	− 5.1
		Carboplatin Paclitaxel	− 8.6
HRAS	4XRV	Ferulic acid	− 6.5
		Caffeic Acid	− 6.7
		Paclitaxel	− 8.4
		Carboplatin	− 6.0
		Carboplatin Paclitaxel	− 8.4