Table 2.
Estimated Slope and Difference in Slopes of Each Neonatal Biomarker by TDF Exposure Between 4 and 30 Days of Birth
| Outcome | Estimated Slope (95% CI) | Estimated Difference in Slopes (95% CI) | |
|---|---|---|---|
| TDF-Exposeda | TDF-Unexposeda | ||
| Creatinine—mg/dL/day | −0.006 (−0.010, −0.002) | −0.008 (−0.015, −0.0002) | 0.002 (−0.008, 0.012) |
| Phosphate—mg/dL/day | −0.06 (−0.11, −0.01) | −0.05, (−0.09, −0.02) | −0.01 (−0.08, 0.06) |
| eGFR—mL/min/1.73 m2/day | 0.96 (0.16, 1.76) | 0.65 (−1.27, 2.56) | 0.31 (−1.84, 2.46) |
| PTRPb—per day | −0.58 (−0.74, −0.04) | −0.084 (−0.44, 0.27) | −0.50 (−0.88, −0.11) |
| 25(OH)Db—ng/mL/day | 0.048 (−0.35, 0.44) | 0.02 (−0.52, 0.56) | 0.03 (−0.68, 0.73) |
| PTHb—pg/mL/day | −1.00, (−2.27, 0.27) | 0.40 (−1.55, 2.35) | −1.40 (−3.68, 0.89) |
| Urine NTxb—per day | 12.82 (5.17, 20.47) | 17.32 (13.44, 21.19) | −4.49 (−12.73, 3.74) |
aNumber of TDF-exposed and TDF-unexposed in each outcome model: creatinine N = 42, N = 18; phosphate N = 42, N = 18; eGFR N = 39, N = 18; PTRP N = 29, N = 9; 25(OH)D N = 30, N = 13; PTH N = 24, N = 11; NTx N = 30, N = 18.
b25(OH)D, 25-hydroxy vitamin D; PTH, parathyroid hormone; PTRP, percent tubular reabsorption of phosphate; urine NTx, urine cross-linked N-telopeptide of type 1 collagen normalized for creatinine.