Table 2.
Application of ultrasound-targeted contrast agents with tumour immunotherapy.
| Contrast agents | Parameters | Ref |
|---|---|---|
| Microbubbles | 300 W, 10 min on-off cycle 1) 0.4 W/cm2 for delivery 2) 1.58 W/cm2 for drug release |
(100) |
| Microbubbles | 1.0 MHz, 3 W/cm2, 50% duty cycle |
(101) |
| Nanobubbles | 1 Hz, 30 W, 20% duty cycle |
(102) |
| Nanobubbles | 1.0 MHz, 1 W/cm2 | (103) |
| Nanodroplet | 1) activated at a centre frequency of 3.5 MHz and an MI of 1.84 (PNP of 3.4 MPa) 2) Vesicle bursting at low frequency application at a centre frequency of 105 kHz and an MI of 0.9 (PNP of 290 kPa) |
(104) |
| Nanodroplet | 0.65 MHz, 2W/cm2, 50% duty cycle |
(105) |
| Nanobubbles | 1.0 MHz, 1.5 W/cm2, 50% duty cycle |
(107) |