Table 1.
Characteristics of Ischemic Stroke Cases and Controls
| Variables | Initial Cohort | Replication Cohort | ||||
|---|---|---|---|---|---|---|
| IS (n=615) | Control (n=615) | P value | IS (n=513) | Control (n=525) | P value | |
| Mean age (years) | 62.47±9.89 | 61.53±8.91 | 0.11 | 62.32±9.52 | 61.45±8.76 | 0.13 |
| Male/female | 408/207 | 311/304 | < 0.001 | 341/172 | 322/203 | 0.093 |
| Smokers, n (%) | 167 (27.2) | 73 (11.9) | < 0.001 | 158 (30.8) | 91 (17.3) | < 0.001 |
| Hypertension, n (%) | 466 (75.8) | 199 (32.4) | < 0.001 | 375 (73.1) | 194 (37.0) | < 0.001 |
| Diabetes, n (%) | 184 (29.9) | 51 (8.3) | < 0.001 | 149 (29.0) | 65(12.4) | < 0.001 |
| Uric acid (mmol/L) | 319.8±88.4 | 322.1±90.9 | 0.72 | 346.54±105.27 | 338.72±96.35 | 0.13 |
| Total cholesterol (mmol/L) | 5.07±1.18 | 5.06±0.99 | 0.94 | 4.84±1.13 | 4.58±1.04 | 0.088 |
| Triglycerides (mmol/L) | 1.62±1.09 | 1.42±0.97 | < 0.001 | 1.64±1.03 | 1.65±1.08 | 0.88 |
| HDL-cholesterol (mmol/L) | 1.30±0.64 | 1.41±0.42 | < 0.001 | 1.22±0.75 | 1.25±0.64 | 0.49 |
| LDL-cholesterol (mmol/L) | 3.07±1.03 | 3.01±0.97 | 0.42 | 3.18±1.05 | 3.05±0.98 | 0.039 |
| HCY (mmol/L) | 11.60±6.06 | 10.33±3.33 | < 0.001 | 13.25±4.85 | 12.13±3.56 | < 0.001 |
| Antihypertensive Medication | 313(50.9) | NA | 242(47.2) | NA | ||
| Antidiabetic Drugs | 153(24.9) | NA | 127(24.8) | NA | ||
| Antiplatelet Therapy | 609(99.0) | NA | 508(99.0) | NA | ||
| Statins | 603(98.0) | NA | 502(95.6) | NA | ||
| Intravenous thrombolysis | 22(3.6) | NA | 17(3.3) | NA | ||
| Endovascular treatment | 89(14.5) | NA | 69(13.5) | NA | ||
Notes: Continuous data are presented as the mean ± SD, median (range) or n (%). P < 0.05 is indicated in bold font.
Abbreviations: IS, Ischemic stroke; HDL-cholesterol, high-density lipoprotein cholesterol; LDL-cholesterol, low-density lipoprotein cholesterol; HCY, Homocysteine; NA, not available.