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Results from the anti-DENV assay for selected compounds from this macrocylce SAR series and the commercial compound LDN-211904. EC50, EC90, and CC50 values reported in [μM].
| 23 | 54 | 55 | 56 | 58 | 75 | 78 | 79 | LDN-211904 | |
|---|---|---|---|---|---|---|---|---|---|
| EC50 [μM] | >10 | 3.7 | 5.3 | >10 | 1.8 | >10 | >10 | >10 | 6.5 |
| EC90 [μM] | >10 | 9.0 | 9.8 | >10 | 2.9 | >10 | >10 | >10 | >10 |
| CC50 [μM] | >10 | >10 | >10 | >10 | 2.9 | >10 | >10 | >10 | >10 |
