Fig 1.

A. Baseline axial fat-saturated, fluid sensitive MRI image of Patient 1’s right shoulder demonstrating multifocal patchy muscle edema (yellow arrows) and subcutaneous reticular edema (white arrow). B. Follow-up axial fat-saturated, fluid sensitive MRI image of Patient 1’s right shoulder after 6 infusions of anifrolumab demonstrating resolution of multifocal patchy muscle edema and subcutaneous reticular edema. C. Baseline axial fat-saturated, fluid sensitive MRI image of Patient 2’s proximal thighs demonstrating muscle edema most prominent in the quadriceps musculature bilaterally (yellow arrows), myofascial edema most prominent along the gracilis muscles bilaterally, diffuse reticular subcutaneous edema (white arrows), and skin edema. D. Follow-up axial fat-saturated, fluid sensitive MRI image of Patient 2’s proximal thighs after 5 infusions of anifrolumab demonstrating improvement in muscle edema, myofascial edema, and subcutaneous and skin edema.