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. 2025 May 16;14(5):598. doi: 10.3390/antiox14050598
−COO− carboxylate anion
−COOH carboxyl group
−OH hydroxyl group
°C degrees Celsius
µg/mL microgram per milliliter (10−6 g per 10−3 L)
µg/L microgram per liter (10−6 g per liter)
µmol micromole (10−6 moles)
1Δg O2 singlet oxygen
1O2 singlet oxygen
11-oxo-12-ene a fragment of an oleanane molecule with a ketone group at C-11 and an unsaturated bond starting at C-12 atom
17-COOH carboxyl group located at the C-17 position of oleanane skeleton
2α-OH hydroxyl group located at the C-2 position of oleanane skeleton and at the α orientation
3α-OH hydroxyl group located at the C-3 position of oleanane skeleton and at the α orientation
3β-OH hydroxyl group located at the C-3 position of oleanane skeleton and at the β orientation
3-Ac-OA 3-acetyloleanolic acid
3-oxo-OA oleanonic acid, “3-oxooleanolic” acid (incorrect name)
3-OH hydroxyl group located at the C-3 position of oleanane skeleton
3-Pht-OA 3-phthaloyloleanolic acid
A2780 ovarian cancer cells
AAE Ascorbic Acid Equivalent
AAPH (2,2′-azobis(2-amidinopropane) dihydrochloride)
ABTS 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid
AcOADs acetylated oleanolic acid dimers
AGEPs advanced glycation end products
A-H electron donor or proton donor
AhR aryl hydrocarbon receptor
AKT/eNOS protein kinase B/endothelial cell nitric oxide synthase
ALP alkaline phosphatase
ALT alanine aminotransferase
AMPK adenosine monophosphate-activated protein kinase
ARE antioxidant response element
B16 murine melanoma cell line
BA betulinic acid
Bax Bcl-2-associated protein x, B-cell lymphoma 2-associated protein x
BHT butylated hydroxytoluene
Br-X-Br α,ω-dihalogenoalkane or α,ω-dihalogenoalkene
BUN blood urea nitrogen
C-12=C-13 double bond between carbon atoms at the 12 and 13 positions of oleanane skeleton
C-2,3 arrangement of two identical elements at the C-2 and C-3 position of the oleanane molecule
C-3 (C-5, etc.) carbon atom at the position number 3 (number 5, etc.) of oleanane skeleton
C57BL/6 common inbred strain of laboratory mouse
CAT catalase
CCl4/NADPH carbon tetrachloride/nicotinamide adenine dinucleotide phosphate
CHP cumine hydroperoxide (correct name: cumene hydroperoxide)
CIRI cerebral ischemia-reperfusion injury
CK-MB creatine kinase-myocardial band
Cl-Au-PPh3 chloro(triphenylphosphine)gold(I); correct abbreviation: (Ph3P)AuCl or Au(PPh3)Cl)
Co(II)/EDTA cobalt(II) ions and ethylenediaminetetraacetic acid
COX-2 Cyclooxygenase-2; prostaglandin-endoperoxide synthase 2
Cu2+ element copper in its +2 oxidation state
CYO1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DMAPP dimethylallyl pyrophosphate
CML carboxymethyl lysine
DMF N,N-dimethylformamide
DN Diabetic nephropathy
DNA deoxyribonucleic acid
Dox doxorubicin
DPPH 1,1-diphenyl-2-picrylhydrazyl
DPPH• 1,1-diphenyl-2-picrylhydrazyl radical
DSS Dahl-salt sensitive (rats)
e− electron, electron donor
ECM extracellular matrix
epi-OA epi-oleanolic acid
e.g., exempli gratia (Lat.), for example (Eng.)
ER endoplasmic reticulum
ERK extracellular signal-regulated kinase
ERS endoplasmic reticulum stress
et al. et alia (Lat.), and others (Eng.)
etc. et cetera (Lat.), and so on (Eng.)
Fe2+ element iron in its +2 oxidation state
Fe3+ element iron in its +3 oxidation state
[Fe(TPTZ)2]3+ ferric-tripyridyltriazine
[Fe(TPTZ)2]3+ reduced ferric-tripyridyltriazine
FRAP Ferric Reducing Antioxidant Power
FTIR Fourier transform infrared spectroscopy
CGLc glutamate-cysteine ligase catalytic subunit
GA glycyrrhetinic acid
GS Granny Smith (apple variety)
GSH glutathione in its reduced form
GSH/GSSG reduced to oxidized glutathione
GSH-Px glutathione peroxidase
H2O2 hydrogen peroxide
HCT-116 colon cancer cell line
HDL high-density lipoprotein
HFF high fat and fructose
HO-1 heme oxygenase-1
HPLC High-Performance Liquid Chromatography
HUVEC human umbilical vein endothelial cells
IC50 minimum inhibitory concentration
i.e., id est (Lat.), that is, it means (Eng.)
IFN-γ interferon-γ
IL-1β interleukin-1 beta
IL-6 interleukin-6
IL-10 interleukin 10
iNOS inducible nitric oxide synthase
IPP isopentenyl pyrophosphate
I/R ischemia/reperfusion
JAK-STAT Janus kinase/signal transducers and activators of transcription
JNK cellular Jun N-terminal kinase
K2CO3 potassium carbonate
K562 chronic myelogenous leukemia
Keap1 Kelch-like ECH-associated protein 1
KIM-1 kidney injury molecule 1
L1210 mouse lymphocytic leukemia cell line
LC3-II lipidated form of microtubule-associated protein 1 light chain
LDH lactate dehydrogenase
LDL low density lipoprotein
Lipo-OANPs oleanolic acid loaded liposomal nanoparticles
LPS lipopolysaccharides
LX-2 human hepatic stellate cell line
MAPK mitogen-activated protein kinase, MAP-kinase
MCF-10A human breast epithelial cell line
MDA malondialdehyde
MDA-MB-231 triple negative human epithelial breast cancer cells
MEP methylerythritol phosphate
MEs microemulsions
ME-1, ME-2 microemulsion no. 1, microemulsion no. 2
mg milligram (10−3 g)
mg/g milligram per gram (10−3 g per gram)
mg/kg milligram per kilogram (10−3 g per 103 g)
MPO myeloperoxidase
miRNAs key regulators of gene expression, play essential roles in the pathobiology of cancer
mmol millimole (10−3 mole)
MMP1 matrix metalloproteinase 1
MMPs matrix metalloproteinases
MPE mango peel extract
MVA mevalonic acid
MWCNTs/SPE screen-printed electrode modified with multi-walled carbon nanotubes
N2 nitrogen gas
NAC N-acetylcysteine
NADPH nicotinamide adenine dinucleotide phosphate
NaHMDS sodium bis(trimethylsilyl)amide
nano-OA nanoparticles of oleanolic acid
NBT nitroblue tetrazolium salt
n.d. no data
N-EGR non-enzymatic glycation reaction
NF-κB nuclear factor kappa B
nm nanometer (10−9 m)
nM nanomole (10−9 moles)
NE nanoemulsion
NO nitric oxide
NOX NADPH-oxidase
Nrf2 nuclear erythroid 2-related transcription factor
NQO1 quinone oxidoreductase
•O2− superoxide radical
•OH hydroxyl radical
OA oleanolic acid
OADs oleanolic acid dimers
OANF oleanolic acid nanofibers
OANPs oleanolic acid nanoparticles
ODG/R oxygen and glucose deprivation and reoxygenation
ORAC Oxygen Radical Absorbance Capacity
P12 pheochromocytoma tumor of the rat adrenal medulla
p62 stress-inducible protein
PAMPA parallel artificial membrane permeability assay
pH the negative decadic logarithm of the proton activity in the solution under scrutiny
PI3K/AKT phosphatidylinositol 3-kinase and activated protein kinase
pKa the negative decadic logarithm of acid dissociation constant
PM particulate matter
PM2 particulate matter with a diameter of 2.5 μm or less
PM10 particulate matter with a diameter of 10 μm or less
PRX-1 peroxidoxin 1
QZG human fetal liver cell line
RAW 264.7 murine macrophages
RD Red Delicious (apple variety)
RG Royal Gala (apple variety)
ROS reactive oxygen species
rpm revolutions per minute
RSA radical scavenging sctivity
SDH succinate dehydrogenase
SGOT serum glutamic-oxaloacetic transaminase
SGP serum glutamic pyruvic transaminase
SHR spontaneously hypertensive rats
SMAD Suppressor of Mothers Against Decapentaplegic
SOD superoxide dismutase
SRB sulforhodamine-B
tBHP tert-butyl hydroperoxide
TAC total antioxidant capacity
TE trolox equivalent
TEM transmission electron microscopy
TGF-β/SMAD2/3 transforming growth factor-β/SMAD 2 and SMAD 3
TGR5 Takeda G protein-coupled receptor 5
THF tetrahydrofurane
TNF-α tumor necrosis factor alpha
Trx thioredoxin
TrxR thioredoxin reductase
UA ursolic acid
UUO unilateral ureteral obstruction
XRD X-ray diffraction