. Author manuscript; available in PMC: 2025 May 27.

Published in final edited form as: Infection. 2024 Aug 8;53(1):241–251. doi: 10.1007/s15010-024-02355-1

Table 3.

Adjusted estimates for primary predictors

	Immunocompetent				Immunocompromised
	Secondary Infection¹		Prolonged Infection²		Secondary Infection¹		Prolonged Infection²
	Odds ratio (95% CI)	P-value	Odds ratio (95% CI)	P-value	Odds ratio (95% CI)	P-value	Odds ratio (95% CI)	P-value
Neutropenia (ANC<1000 on Days 0–2)	0.78 (0.17, 2.53)	0.705	2.39 (0.63, 7.77)	0.188	2.99 (1.14, 8.19)	0.026	0.93 (0.28, 3.00)	0.898
Neutropenia (ANC<1000 on Days 0–5)	1.16 (0.15, 5.34)	0.866	4.50 (0.85, 20.98)	0.075	5.34 (1.92, 15.84)	0.001	1.02 (0.29, 3.52)	0.980
Lymphopenia (ALC<1000 on Days 0–2)	1.55 (0.79, 3.05)	0.198	0.72 (0.28, 1.76)	0.473	2.57 (0.75, 12.09)	0.142	0.37 (0.08, 1.75)	0.201
Lymphopenia (ALC<1000 on Days 0–5)	2.09 (1.03, 4.17)	0.042	1.15 (0.44, 2.81)	0.768	14.19 (2.69, 262.22)	<.001	0.64 (0.13, 3.13)	0.568
Confirmed IPMOF (Days 0–5)	1.85 (0.69, 4.55)	0.213	1.84 (0.54, 5.49)	0.313	0.91 (0.30, 2.57)	0.862	2.14 (0.64, 7.04)	0.211
Lowest TNF–alpha (Days 0–2) ³	1.00 (1.00, 1.00)	0.402	1.00 (1.00, 1.00)	0.809	--	--	1.00 (1.00, 1.00)	0.063

Results are based on models adjusting for plasma exchange and the number of organ failures on Day 0.

Results are based on models adjusting for primary infection, platelets transfusion, and tracheal aspirate sample collection.

For immunocompromised patients, there were insufficient counts to support the multivariable logistic regression model with secondary infection as outcome.