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. 2025 May 11;13(10):1115. doi: 10.3390/healthcare13101115

Table 5.

Multivariate logistic regression analysis of factors associated with COVID-19 vaccine hesitancy.

Variables Adjusted OR (95% CI) p-Value
Socio-demographic factors
Females (vs. males) 2.645 (1.180–5.929) 0.018
Age groups
17–20 (ref *) years 1
21–24 years 0.601 (0.297–1.216) 0.157
≥25 years 1.212 (0.482–3.048) 0.683
Area of study [Health science vs. others (ref *)] 0.320 (0.099–1.033) 0.057
Year of study
First or second (ref *) 1
Third or above 0.504 (0.179–1.423) 0.196
Single vs. married (ref *) 3.073 (0.684–13.800) 0.143
Current vs. former/no smoking (ref *) 2.359 (1.080–5.153) 0.031
Health status factors
Chronic health condition [(≥1 vs. o (ref *)] 0.885 (0.355–2.205) 0.793
Self-rated health good/excellent vs. fair/bad (ref *) 0.645 (0.288–1.445) 0.286
Self-rated as vulnerable group [vs no (ref *)] 0.407 (0.107–1.549) 0.188
Living with vulnerable individuals [vs no (ref *)] 0.667 (0.335–1.331) 0.251
Experiences
Previous COVID-19 infection [moderate/severe vs. mild/none(ref *)] 1.718 (0.674–4.376) 0.257
COVID-19 vaccinationDoses [(≥3 doses vs. <3 doses (ref *)] 0.136 (0.054–0.339) <0.001
COVID-19 vaccinationSide effects [moderate severe vs. none/mild(ref *)] 1.940 (0.624–6.031) 0.252
Flu vaccination [yes vs. no (ref *)] 0.439 (0.212–0.910) 0.027
Attitudes [yes vs. no (ref *)]
Fear of vaccine side effects 2.135 (1.126–4.049) 0.020
Reported vaccine side effects among family/friends 3.079 (1.177–8.056) 0.022
Low perceived efficacy of vaccine 12.132 (3.527–41.734) <0.001
Early vaccine distribution 1.718 (0.893–3.304) 0.105
No need due to previous COVID-19 infection 3.393 (1.047–11.002) 0.042
Belief that infection confers much greater immunity than a vaccine 9.558 (1.190–76.742) 0.034
Perception of low susceptibility to disease or possible infection would not be severe 9.368 (1.099–79.877) 0.041
Information insufficiency 0.942 (0.491–1.809) 0.858
Belief that vaccine development is a way for pharmaceutical companies to make a profit/conspiracy belief 2.520 (0.742–8.557) 0.138
Pregnancy 9.172 (0.037–10.793) 0.024
Sources of information [yes vs. no (ref *)]
Anti-vaccination campaigns 3.365 (0.385–29.384) 0.272
Doctors’ recommendation/scientist opinion 0.108 (0.013–0.870) 0.037
Media/internet 6.218 (1.692–22.848) 0.006
Government trust 4.831 (0.494–47.223) 0.176
Religious beliefs 3.980 (0.455–34.849) 0.212
ATAVAC scale (total score) 0.216 (0.099–0.472) <0.001
Subscales
Value of adult vaccination subscale 0.137 (0.058–0.321) <0.001
Safety concerns subscale 0.615 (0.475–0.796) <0.001
Perceived barriers subscale 1.004 (0.725–1.392) 0.979

* The reference category against which comparisons are being conducted.