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. 2025 Apr 28;18(5):640. doi: 10.3390/ph18050640
SAM S-adenosyl-methionine
TME Tumor microenvironment
MATs Methionine adenosyltransferases
SAH S-Adenosylhomocysteine
5-MTHF 5-methyltetrahydrofolate
MTA Methylthioadenosine
MTAP Methylthioadenosine phosphorylase
5,10-MTHF 5,10-methylene tetrahydrofolate
mTORC1 Mechanistic target of rapamycin complex 1
DNMTs DNA methyltransferases
CpG Cytosine–phosphate–guanine
DAPK1 Death-associated protein kinase 1
PUMA P53 upregulated modulator of apoptosis
BNIP3 BCL2 interacting protein 3
lncRNA Long non-coding RNA
PET Positron emission tomography
WTAP Wilms tumor 1-associated protein
SLC Solute carriers
PD-L1 Programmed cell death ligand 1
VISTA V-domain immunoglobulin suppressor of T cell activation
ATAD2 ATPase family AAA domain-containing protein 2
PRMT Protein arginine methyltransferase
ACSL3 Acyl-CoA synthetase long chain family member 3
TNBC Triple-negative breast cancer
PARP Poly (ADP-ribose) polymerase
CSCs Tumor stem cells
ROS Reactive oxygen species
MCR Methionine/cystine restriction
CHAC1 Cation transport regulator homolog 1
MR Methionine restriction
MAPK14 Mitogen-activated protein kinase P38
MK2 MAPK-activated protein kinase 2
GSH Glutathione
NF-κB Nuclear factor kappa B
PD-1 Programmed cell death protein 1
CAR-T Chimeric antigen receptor T-cell
cGAS Cyclic GMP-AMP synthase
UHRF1 Ubiquitin-like with plant homeodomain and RING finger domains 1
STING Stimulator of interferon genes
MGL Methionine γ lyase
hCGL Human enzyme cystathionine-γ-lyase
MRD Methionine restriction diet
rMETase Recombinant methioninase