Table 5.
Summary results for correlation analysis (between zinc and other biomarkers).
| Other Biomarkers | At Baseline | At Week 24 | |||
|---|---|---|---|---|---|
| Correlation Coefficient | p-Value | Correlation Coefficient | p-Value | ||
| Metabolic Markers | |||||
| BMI (kg/m2) | 0.0511 | 0.63 | −0.0771 | 0.50 | |
| Weight (lbs) | 0.0863 | 0.41 | −0.0844 | 0.46 | |
| Waist-umbilicus (cm) | −0.0115 | 0.91 | 0.0191 | 0.87 | |
| Systolic blood pressure (mmHg) | 0.1029 | 0.33 | 0.1457 | 0.21 | |
| Diastolic blood pressure (mmHg) | 0.1896 | 0.07 | 0.1668 | 0.15 | |
| Non-HDL cholesterol (mg/dL) | −0.0061 | 0.95 | 0.1146 | 0.32 | |
| HDL (mg/dL) | 0.1047 | 0.32 | −0.1329 | 0.25 | |
| LDL (mg/dL) | 0.016 | 0.88 | 0.0113 | 0.92 | |
| VLDL (mg/dl) | −0.0404 | 0.71 | 0.2529 | 0.03 | |
| Cholesterol (mg/dL) | 0.0392 | 0.71 | 0.0711 | 0.54 | |
| Chol:HDL ratio | −0.0338 | 0.75 | 0.1935 | 0.09 | |
| Triglycerides (mg/dL) | −0.0227 | 0.83 | 0.2715 | 0.02 | |
| 10-year ASCVD (%) | 0.1096 | 0.29 | 0.286 | 0.01 | |
| Metabolic syndrome | −0.0715 | 0.49 | −0.0696 | 0.55 | |
| Endothelial Function | |||||
| Reactive Hyperemic Index | 0.0013 | 0.99 | 0.0572 | 0.64 | |
| Augmentation Index | 0.0335 | 0.75 | 0.1219 | 0.30 | |
| Inflammatory Markers | |||||
| hsCRP (ng/mL) | 0.068 | 0.52 | −0.0551 | 0.65 | |
| sCD14 (ng/mL) | −0.0835 | 0.43 | −0.1329 | 0.27 | |
| sCD163 (ng/mL) | −0.0687 | 0.51 | 0.0484 | 0.69 | |
| sTNF-RI (pg/mL) | −0.0059 | 0.96 | −0.0052 | 0.97 | |
| sTNF-RII (pg/mL) | 0.031 | 0.77 | −0.0266 | 0.82 | |
| D-dimer (ng/mL) | 0.0908 | 0.39 | 0.0623 | 0.60 | |
| oxLDL (U/L) | −0.0415 | 0.69 | 0.1365 | 0.25 | |
| IL−6 (pg/mL) | −0.0262 | 0.80 | −0.149 | 0.21 | |
| VCAM (ng/mL) | −0.2043 | 0.05 | 0.0891 | 0.46 | |
| ICAM (ng/mL) | −0.0278 | 0.79 | −0.0419 | 0.73 | |
| IP−10 (pg/mL) | 0.0874 | 0.40 | −0.0372 | 0.76 | |
| Gut Integrity Markers | |||||
| LBP (ng/mL) | −0.0923 | 0.38 | 0.0987 | 0.41 | |
| IFAB (pg/mL) | −0.2286 | 0.03 | −0.0082 | 0.95 | |
| BDG (pg/mL) | −0.0639 | 0.54 | 0.1719 | 0.15 | |
| Zonulin (ng/mL) | 0.0422 | 0.69 | −0.0699 | 0.56 | |
BMI = body mass index; LDL = low-density lipoprotein; HDL = high-density lipoprotein; VLDL = very-low-density lipoprotein; ASCVD: atherosclerotic cardiovascular disease; hsCRP = high-sensitivity C-reactive protein; sCD14 = soluble CD14; sCD163 = soluble CD163; sTNF-RI = soluble tumor necrosis factor receptor−1; sTNF-RII = soluble tumor necrosis factor receptor−2; oxLDL = oxidized LDL; IL−6 = interleukin−6; VCAM: vascular cell adhesion molecule−1; ICAM = intercellular adhesion molecule−1; IP-10 = interferon-gamma-inducible protein of 10 kDa; LBP = lipopolysaccharide-binding protein; IFAB = intestinal fatty-acid-binding protein; BDG = (1,3)-β-d-glucan.