Figure 2.

Structural modification of nifuroxazide to obtain new derivatives with anti-T. cruzi, anti-L. mexicana, and anti-Mycobacterium tuberculosis activity. The pink arrows indicate the final compounds reported by Kannigadu et al. [19], Badenhorst et al. [20], and those obtained in this investigation. The blue square highlights the chemical modification to Nfz performed by Kannigadu et al., and the yellow square indicates the substituents incorporated into Nfz reported by Badenhorst et al. The green box shows the substituents incorporated into the 4-hydroxybenzhydrazide fragment in this work.