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. 2025 May 13;18(5):716. doi: 10.3390/ph18050716
ALK5 Activin receptor-like kinase 5
ASO Antisense oligonucleotide
ATP Adenosine triphosphate
CDK Cyclin-dependent kinase
CN Carbonitrile
C-H Carbon–hydrogen
CTLs Cytotoxic T lymphocytes
DNA Deoxyribonucleic acid
EMT Epithelial–mesenchymal transition
EW-7197 TGF-βR1 kinase inhibitor (compound 9)
GS Glycine-serine-rich
H-bond Hydrogen bond
IC50 Half maximal inhibitory concentration
IN-1130 TGF-βR1 kinase inhibitor (compound 7)
MAPK Mitogen-activated protein kinase
MOE Molecular operating environment
NHLF Normal human lung fibroblast
NK Natural killer (cells)
PD-1 Programmed cell death protein 1
PDB Protein Data Bank
R1, R2, R3 Variable substituent groups in a molecule
RNA Ribonucleic acid
SAR Structure–activity relationship
SBE SMAD binding element
SMAD Homolog of mothers against decapentaplegic (a family of signaling proteins)
SMI Small molecule inhibitor
sTGF-βR3 Soluble transforming growth factor beta receptor type 3
TGF-β Transforming growth factor beta
TGF-βR1 Transforming growth factor beta receptor type 1
TGF-βR2 Transforming growth factor beta receptor type 2
TGF-βR3 Transforming growth factor beta receptor type 3