TABLE 2.
T-cell epitopes recognized by PBMC of at least 30% of patients
| No. | Amino acid position | Sequence (genotype 1b) | Frequency of recognition [no. (%)] | Specific CD4+ T-cell clones |
|---|---|---|---|---|
| p5 | 1242-1261 | AAYAAQGYKVLVLNPSVAAT | 8 (40) | (+)a |
| p22 | 1388-1407 | GRHLIFCHSKKKCDELATKL | 9 (45) | + |
| p24 | 1406-1425 | KLVAMGINAVAYYRGLDVSV | 8 (40) | + |
| p29 | 1450-1469 | SVIDCNTCVTQTVDFSLDPT | 6 (30) | (+)a |
| p37 | 1535-1554 | TTVRLRAYMNTPGLPVCQDH | 8 (40) | + |
| p41 | 1575-1594 | QTKQSGENLPYLVAYQATVC | 8 (40) | + |
| p42 | 1585-1604 | YLVAYQATVCARAQAPPPSW | 10 (50) | + |
| p50 | 1665-1674 | GVLAALAAYCLSTGCVVIVG | 6 (30) | − |
| p60 | 1765-1784 | MWNFISGIQYLAGLSTLPGN | 6 (30) | + |
| p61 | 1775-1794 | LAGLSTLPGNPAIASLMAFT | 11 (55) | + |
| p64 | 1805-1824 | QTLLFNILGGWVAAQLAAPG | 8 (40) | + |
| p74 | 1905-1924 | HVGPGEGAVQWMNRLIAFAS | 6 (30) | − |
| p79 | 1955-1974 | QLLRRLHQWISSECTTPCSG | 6 (30) | − |
a
CD4+ T-cell clones specific for this epitope have previously been characterized and published by our group (3).