TABLE 2.

Expression profile of genes involved in the IFN-α/β signaling pathway in mouse brain infected with B2C or SHBRV i.c. or i.m.

Gene category and identification	Fold change over control
	Infected i.c. with:		Infected i.m. with:
	B2C	SHBRV	B2C	SHBRV
Interferon genes
IFN-α2	2	Nb	3	N
IFN-α4	8	6	9	N
IFN-α5	9	N	8	N
IFN-β	3	N	3	2
Interferon signaling genes
Cbp/p300-transactivator	2	2	2	N
Stat1	32	18	14	9
Stat2	13	4	10	4
Stat3	4	5	5	N
IRF-1	6	3	9	2
IRF-2	3	N	5	N
IRF-7	11	6	30	7
Jak-2	2	N	2	N
PKR	3	N	6	4
Interferon effector genes
2′-5′-OAS-1B	15	10	13	6
2′-5′-OAS-1G	13	5	13	5
2′-5′-OAS-2	4	N	6	3
2′-5′-OAS-3	2	N	5	N
2′-5′-OAS-like 1	7	3	11	3
2′-5′-OAS-like 2	42	18	45	26
ADAR, RNA specific	3	2	−2	N
MHC I antigen	3	N	4	N
Mx 1	388	91	119	18
Mx 2	56	15	147	24
Interferon-activated genes
202B	315	147	478	49
203	5	2	23	N
204	49	12	478	16
205	45	11	147	12
IFN-induced protein 1a	37	21	24	N
IFN-induced protein 2a	256	128	208	74
IFN-induced protein 3a	45	18	60	30

^aIFN-induced transmembrane protein with tetratricopeptide repeats 1, 2, and 3.

^bN, no change.