TABLE 3.
Expression profile of inflammatory genes in mouse brain infected with B2C or SHBRV i.c. or i.m.
| Gene category and identification | Fold change over control
|
|||
|---|---|---|---|---|
| Infected i.c. with:
|
Infected i.m. with:
|
|||
| B2C | SHBRV | B2C | SHBRV | |
| Toll-like receptors | ||||
| TLR1 | 3 | Na | 2 | 2 |
| TLR2 | 6 | 4 | 5 | N |
| TLR3 | 10 | 6 | 11 | 4 |
| Chemokines | ||||
| (C-C) MCP-5 | 60 | 60 | 39 | 37 |
| (C-C) MCP-1 | 28 | 8 | 12 | 3 |
| (C-C) MIP-1α | 104 | 34 | 111 | N |
| (C-C) MIP-1β | 5 | N | 4 | N |
| (C-C) RANTES | 56 | 12 | 91 | 5 |
| (C-C) MCP-3 | 37 | 11 | 7 | 3 |
| (C-X-C) MIP-2α | 6 | 7 | 3 | 3 |
| (C-X-C) IP-10 | 84 | 37 | 158 | 26 |
| (C-X-C) L11 | 16 | 3 | 25 | 3 |
| (C-X-C) BLC | 3 | N | 3 | N |
| (C-X-C) MIP-2β | 4 | 5 | 3 | 3 |
| (C-X-C) MIG | 34 | 5 | 42 | 3 |
| Cytokinesb | ||||
| IL-6 | 4 | 3 | 15 | 3 |
| IL-12β | 3 | 2 | N | N |
| IL-12 receptor β1 | 3 | N | 20 | 11 |
| IL-13 receptor α1 | 5 | N | N | N |
| TGF-β-regulated gene 1 | 3 | N | 2 | N |
| TGF-β induced, 68 kDa | 7 | 2 | 28 | N |
| TNFR-12α | 15 | 17 | 7 | N |
| TNFR-5 | 2 | N | N | N |
| TNF-α-induced protein 2 | 7 | 8 | 3 | N |
| Complement genes | ||||
| c1q-α | 2 | 2 | N | N |
| c1q-β | 3 | 3 | 2 | 2 |
| c1q-γ | 3 | 2 | 3 | N |
| c1r | 56 | 20 | 18 | 2 |
| c1s | 3 | N | 158 | 5 |
| c2 | 4 | N | 4 | 2 |
| c3 | 30 | 8 | 119 | N |
| c4 | 5 | 4 | 8 | 4 |
a
N, no change.
b
TGF, transforming growth factor; TNF, tumor necrosis factor; TNFR, TNF receptor.