TABLE 3.
Infectivity, in vitro replicative capacity, and IC50 values of sera and sCD4 against mutant strains lacking glycosylation sites distal to receptor contact residuesa
| Viral strain | Infectivity (% of WT) | Growth in tissue culture | IC50 sera (inverse dilution) | IC50 sCD4 (ng/μl) |
|---|---|---|---|---|
| SIV239 | NA | Yes | <20 | 17.8 |
| g2 | 28 | Yes | <20 | 7.5 |
| g12 | 46 | Yes | 20 | 6.3 |
| g13 | 170 | Yes | 20 | 5.0 |
| g14 | 5 | Yes | 23 | 14 |
| g15 | 0 | No | NA | NA |
| g15TA | 0 | No | NA | NA |
| g17 | 41 | Yes | 20 | 11.0 |
| g21 | 120 | Yes | 12 | 11.0 |
| g14,15 | 0 | No | NA | NA |
a
NA, nonapplicable. Mutants were tested for their ability to grow in long-term tissue culture in the CEMx174 cell line.