Table 2.

SPOP gene mutations.

SPOP domain	Nucleotide substitution	Amino acid substitution	Reference
MATH∗	T > G	Y87C	[13, 14]
	C > T	F102C	[14, 15]
	C > T	F102L	[13]
	G > A	F133L	[16]
	C > G	F133V	[14, 15]
	G > C	F125C	[16]
	T > A	W131R	[16]
	T > G	W131G	[14]
BTB	C > G	Y87C	[17]
BACK	NIL	NIL	NIL
NLS	NIL	NIL	NIL

Note: NIL (No discovered mutation).

^∗Found to be hotspot for various mutations.