TABLE 7.
Effectiveness of auto‐fluorescence imaging in guiding treatment choices for chronic wounds.
| Study | Intervention | Effectiveness of auto‐fluorescence in guiding treatment (antibiotics, dressing or change of treatment) | |||
|---|---|---|---|---|---|
| Y/N | Methods | Wound changes‐Intervention group (with FL‐guidance) | Wound changes‐control group | ||
| DaCosta et al. [37] | PRODIGI | Yes | In part 2, wound area was tracked in a separate group of 12 patients over approx. 6 months‐3 contiguous 2 month periods, comparing treatment delivered with control and with FL‐guidance. |
Wound area changes (N = 12 patients, 6 months): −0.046 cm2/day (significant decrease, p = 0.017) Rate of wound closure over 30 days: 1.38 cm2 (decrease) |
Wound area changes (N = 12 patients, 6 months): −0.005 cm2/day (insignificant decrease, p = 0.579) Rate of wound closure over 30 days: 0.09 cm2 (decrease) |
| Raizman et al. [39] | MolecuLight i:X, Toronto, ON, Canada. | Yes | The device also identified off‐site bacteria, prompting precise cleaning actions. Additional antimicrobial treatments. | More targeted debridement in 85% of assessed wounds | Not specified |
| Raizman et al. [40] | MolecuLight i:X, Toronto, ON, Canada. | Yes | Management plan changed according to AF | Not specified | |
| Le et al. [52] | MolecuLight i:X, Toronto, ON, Canada. | Yes |
Management plan changed according to AF in 68.9% of wounds. AFI‐guided wound bed preparation in 84.6% of wounds |
Improvements in patient care due to FL: 90.00% Change in diagnosis due to FL: 52.30% Treatment plan changes due to FL: 68.90% |
Not specified |
| Rahma et al. [42] | MolecuLight i:X, Toronto, ON, Canada. | Yes |
Management plan changed according to AF Enhanced wound debridement dressings changed to antimicrobial dressings |
The median (%) wound‐area reduction at 4‐weeks: 40.7% At 12‐weeks after randomization, the median (%): 91.3% |
The median (%) wound‐area reduction at 4‐weeks: 38.6% At 12‐weeks after randomization, the median (%): 72.8% |