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. 2025 May 28;14:55. doi: 10.1186/s13756-025-01552-3

Table 2.

The results of a multilevel linear regression model examining the associations between drug categories, countries, sectors and COVID times on the square root of drug consumption. Coefficients and their p-values

Stratification parameters β 95% CI P valuea
Intercept 0.91 0.76, 1.06  < 2e-16 ***
Drug categories
 Carbapenems Referent
 Polymyxins −0.17 −0.35, −0.002 0.04 *
 Tetracyclines 0.4 0.25, 0.55 3.22e-07***
 Penicillins 1.08 0.93, 1.23  < 2e-16 ***
 Other beta-lactams −0.01 −0.16, 0.14 0.91
 Sulfonamides/trimethoprim −0.06 −0.21, 0.09 0.44
 Macrolides, lincosamides and streptogramins 0.05 −0.1, 0.2 0.54
 Quinolones −0.08 −0.24, 0.07 0.27
 Other antibacterials 0.20 0.05, 0.35 0.01 **
Countries
 Denmark Referent
 Finland 0.06 −0.03, 0.16 0.19
 Iceland 0.08 −0.01, 0.18 0.08
 Norway −0.004 −0.09, 0.09 0.93
 Sweden −0.06 −0.15, 0.04 0.25
Sectors
 Community Referent
 Hospital −0.76 −0.83, −0.69  < 2e-16 ***
COVID-19 time
 Per-COVID-19 time Referent
 Pre-COVID-19 time 0.05 −0.01, 0.11 0.1

Residual standard error: 0.3322 on 458 degrees of freedom

Multiple R-squared: 0.7458, Adjusted R-squared: 0.7381

F-statistic: 96 on 14 and 458 DF, p-value: < 2.2e-16

aSignificant codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05