Table 1. Sample demographics of menopausal hormone therapy (MHT) never-, current, and past- users in the whole sample.
| MHT User Status | p-value | |||||
|---|---|---|---|---|---|---|
| Never | Current | Past | Never vs | Never vs | Current vs | |
| N | 12,012 | 1153 | 6681 | Current | Past | Past |
| Age* | 61.6±7.1 | 60.1±6.8 | 67.5±6.2 | <0.001 | <0.001 | <0.001 |
| Ethnic Background, N (%) | 0.084 | <0.001 | 0.824 | |||
| White | 11,590 (96.6) | 1128 (98.0) | 6555 (98.2) | |||
| Asian | 103 (0.9) | 5 (0.4) | 27 (0.4) | |||
| Black | 96 (0.8) | 4 (0.3) | 23 (0.3) | |||
| Chinese | 54 (0.5) | 1 (0.1) | 12 (0.2) | |||
| Mixed | 81 (0.7) | 5 (0.4) | 27 (0.4) | |||
| Other ethnic group | 73 (0.6) | 8 (0.7) | 28 (0.4) | |||
| Education, N (%) | 0.260 | <0.001 | <0.001 | |||
| College/University degree | 6,123 (51.0) | 606 (52.6) | 2,813 (42.1) | |||
| O levels/GCSEs or equivalent | 2,234 (18.6) | 203 (17.6) | 1,447 (21.7) | |||
| A levels/AS levels or equivalent | 1,656 (13.8) | 135 (11.7) | 758 (11.3) | |||
| CSEs or equivalent | 471 (3.9) | 52 (4.5) | 247 (3.7) | |||
| NVQ/HND/HNC or equivalent | 414 (3.4) | 38 (3.3) | 279 (4.2) | |||
| Other professional qualifications | 602 (5.0) | 70 (6.1) | 523 (7.8) | |||
| None of the above | 512 (4.3) | 49 (4.2) | 613 (9.2) | |||
| Lifestyle score | 1.7±1.2 | 1.8±1.3 | 1.7±1.2 | 0.009 | 0.076 | 0.089 |
| BMI* (m2/kg) | 26.0±4.8 | 25.5±4.4 | 26.2±4.6 | 0.003 | 0.003 | <0.001 |
| Menopausal Status, N (%) | <0.001 | <0.001 | <0.001 | |||
| No | 962 (8.0) | 45 (3.9) | 37 (0.6) | |||
| Yes | 9,905 (82.5) | 769 (66.7) | 5,528 (82.8) | |||
| Not sure – had a hysterectomy | 545 (4.5) | 247 (21.4) | 1,057 (15.8) | |||
| Not sure – other reason | 600 (5.0) | 92 (8.0) | 58 (0.9) | |||
| Oophorectomy, yes, N (%) | 443 (3.7) | 224 (19.4) | 1172 (17.7) | <0.001 | <0.001 | 0.159 |
| Hysterectomy, yes, N (%) | 518 (4.5) | 117 (12.5) | 1083 (18.8) | <0.001 | <0.001 | <0.001 |
| APOE ε4 status, carrier, N (%) | 3134 (27.5) | 284 (26.2) | 1557 (24.7) | 0.398 | <0.001 | 0.278 |
| APOE ε4, allele, N (%) | 0.649 | <0.001 | 0.460 | |||
| non-carrier | 8264 (72.5) | 798 (73.8) | 4759 (75.3) | |||
| ε3/ε4 | 2853 (25.0) | 257 (23.8) | 1424 (22.5) | |||
| ε4/ ε4 | 281 (2.5) | 27 (2.5) | 133 (2.1) | |||
| Age started MHT* | 49.8±6.5 | 47.9±5.6 | <0.001 | |||
| Age last used MHT* | 60.1±6.8 | 53.9±6.1 | <0.001 | |||
| Duration of MHT use* | 10.3±8.6 | 6.0±5.6 | <0.001 | |||
*
Mean ± Standard Deviation. Age is given in years. Abbreviations: N, sample size; GCSE, General Certificate of Secondary Education; CSE, Certificate of Secondary Education; NVQ, National Vocational Qualification; BMI, body mass index; APOE, apolipoprotein. Significant differences between groups based on t/χ2 tests are highlighted in bold.