Table 2. Sample demographics of menopausal hormone therapy (MHT) users with and without a history of hysterectomy +/-bilateral oophorectomy in the whole sample.
| MHT Users | p-value | ||||||
|---|---|---|---|---|---|---|---|
| No Surgery | Hysterectomy | Oophorectomy | No vs | No vs | Hyster vs | ||
| N | 5,510 | 544 | 1,407 | Hyster | Oopho | Oopho | |
| Age* | 66.1±6.9 | 69.0±5.6 | 66.7±6.7 | <0.001 | 0.003 | <0.001 | |
| Ethnic Background, N (%) | 0.710 | 0.272 | 0.569 | ||||
| White | 5408 (98.3) | 535 (98.5) | 1370 (97.4) | ||||
| Asian | 24 (0.4) | 2 (0.4) | 8 (0.6) | ||||
| Black | 15 (0.3) | 3 (0.6) | 8 (0.6) | ||||
| Chinese | 9 (0.2) | 0 (0.0) | 4 (0.3) | ||||
| Mixed | 22 (0.4) | 2 (0.4) | 6 (0.4) | ||||
| Other ethnic group | 23 (0.4) | 1 (0.2) | 10 (0.7) | ||||
| Education, N (%) | <0.001 | <0.001 | 0.197 | ||||
| College/University degree | 2559 (46.4) | 184 (33.8) | 557 (39.6) | ||||
| O levels/GCSEs or equivalent | 1,099 (19.9) | 132 (24.3) | 323 (23.0) | ||||
| A levels/AS levels or equivalent | 631 (11.5) | 66 (12.1) | 156 (11.1) | ||||
| CSEs or equivalent | 206 (3.7) | 18 (3.3) | 54 (3.8) | ||||
| NVQ/HND/HNC or equivalent | 209 (3.8) | 24 (4.4) | 63 (4.5) | ||||
| Other professional qualifications | 387 (7.0) | 60 (11.0) | 114 (8.1) | ||||
| None of the above | 419 (7.6) | 60 (11.0) | 140 (10.0) | ||||
| Lifestyle score* | 1.7±1.2 | 1.6±1.2 | 1.8±1.2 | 0.323 | 0.066 | 0.044 | |
| BMI (kg/m2) * | 25.9±4.50 | 26.1±4.2 | 26.7±4.7 | 0.260 | <0.001 | 0.011 | |
| Menopausal Status, N (%) | <0.001 | <0.001 | <0.001 | ||||
| No | 81 (1.5) | 0 (0.0) | 1 (0.1) | ||||
| Yes | 5,290 (96.0) | 444 (81.6) | 615 (43.7) | ||||
| Not sure – had a hysterectomy | 0 (0.0) | 99 (18.2) | 781 (55.5) | ||||
| Not sure – other reason | 139 (2.5) | 1 (0.2) | 10 (0.7) | ||||
| Hysterectomy, yes, N (%) | 666 (89.4) | ||||||
| APOE ε4 status, carrier, N (%) | 1317 (25.3) | 113 (21.9) | 345 (25.9) | 0.100 | 0.678 | 0.085 | |
| APOE ε4, allele, N (%) | 0.095 | 0.427 | 0.161 | ||||
| non-carrier | 3881 (74.7) | 402 (78.1) | 985 (74.1) | ||||
| ε3/ε4 | 1194 (23.0) | 107 (20.8) | 320 (24.1) | ||||
| ε4/ ε4 | 123 (2.4) | 6 (1.2) | 25 (1.9) | ||||
| Age at menopause* | 50.0±5.1 | 43.1±6.8 | 46.9±6.3 | <0.001 | <0.001 | <0.001 | |
| Age started MHT* | 49.2±5.3 | 46.9±5.7 | 45.6±6.1 | <0.001 | <0.001 | <0.001 | |
| Age last used MHT* | 54.7±6.1 | 55.0±7.4 | 55.2±7.4 | 0.312 | 0.014 | 0.646 | |
| Duration of MHT use* | 5.5±5.4 | 8.1±6.6 | 9.6±7.8 | <0.001 | <0.001 | <0.001 | |
| Age MHT rel Age Menopause | <0.001 | <0.001 | <0.001 | ||||
| Same age | 1177 (24.7) | 89 (19.7) | 303 (46.2) | ||||
| After | 1659 (34.8) | 283 (62.7) | 170 (25.9) | ||||
| Before | 1931 (40.5) | 79 (17.5) | 183 (27.9) | ||||
| Age at oophorectomy* | 47.7±8.2 | ||||||
| Age at hysterectomy* | 44.5±10.0 | 46.9±7.9 | <0.001 | ||||
| Age Oopho rel Age Menopause | |||||||
| Same age | 301 (47.8) | ||||||
| After | 271 (43.0) | ||||||
| Before | 58 (9.2) | ||||||
| Age Oopho rel Age MHT | |||||||
| Same age | 740 (59.0) | ||||||
| After | 367 (29.2) | ||||||
| Before | 148 (11.8) | ||||||
| Age Hyster rel Age Menopause | <0.001 | ||||||
| Same age | 278 (61.6) | 324 (54.8) | |||||
| After | 110 (24.4) | 214 (36.2) | |||||
| Before | 63 (14.0) | 53 (9.0) | |||||
| Age Hyster rel Age MHT | <0.001 | ||||||
| Same age | 80 (17.2) | 746 (61.2) | |||||
| After | 111 (23.9) | 296 (24.3) | |||||
| Before | 274 (58.9) | 177 (14.5) | |||||
*
Mean ± Standard Deviation. Age is given in years. Hysterectomy/hyster included females without bilateral oophorectomy; Oophorectomy/Oopho constitutes bilateral oophorectomy (+/-hysterectomy; no hysterectomy n=X, with hysterectomy n=Y). Abbreviation: N, sample size; GCSE, General Certificate of Secondary Education; CSE, Certificate of Secondary Education; NVQ, National Vocational Qualification; BMI, body mass index; APOE, apolipoprotein. Significant differences between groups based on t/χ2 tests are highlighted in bold.