Table 3.
Adverse Events and Complications
| Cyclosporin + Sirolimus (n = 37) | Cyclosporin monotherapy (n = 37) | P | |
|---|---|---|---|
| Serious adverse events | 1 (Diarrhea) | 0 | NS |
| Adverse events | |||
| Hyperlipidemia | 27 | 24 | NS |
| Anemia | 13 | 13 | NS |
| eGFR reduction | 2 | 10 | 0.012 |
| Hyperkalemia | 2 | 5 | NS |
| Creatine kinase increase (asymptomatic) | 4 | 3 | NS |
| Abdominal pain | 1 | 2 | NS |
| Diabetes | 2 | 1 | NS |
| Myalgia | 0 | 2 | NS |
| Headache | 0 | 2 | NS |
| Nausea or vomiting | 0 | 1 | NS |
| Gingival event | 0 | 1 | NS |
| Muscle cramps | 0 | 1 | NS |
| Complications of nephrotic syndrome | |||
| Edema | 21 | 25 | NS |
| Hypertension | 5 | 8 | NS |
| Thrombotic events | 0 | 0 | NS |
| Infections | 1 | 2 | NS |
| Acute kidney injury | 0 | 0 | NS |