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. 2025 May 30;26:547. doi: 10.1186/s12864-025-11689-5

Table 5.

Summary of GWAS analysis in aquaculture bivalves for heat tolerance

Species Bay Scallop Argopecten irradians irradians Hybrids of Crassostrea angulata × C. gigas Dwarf clam Mulinia lateralis Northern quahogs Mercenaria mercenaria
Reference [53] [52] [55] Current study
Heat challenge Heart rate for Arrhenius break temperature Submerging at 42℃ for 2 h, then back to normal temperature At 30℃ for 10 days, then back to 22℃ for recovery At 1℃/day from 24 to 35℃ and stay 2 days, back 24℃
Genotyping Gill. Sequencing using multi-isoRAD approach Gill. Sequencing Gill. Sequencing using the iso-RAD approach Muscle/hemocytes. ∼66K SNP array
Associated SNP 14 SNPs

18 SNPs

26 genes

3 SNPs

10 genes

1 SNP
Major Genes PC4 gene for repairing DNA Ca2+ influx, transcriptional signal regulation, protein degradation, or folding ETHR/EHF signaling pathway See Table 4
Heritability NA NA 0.375 ± 0.127 0.680 ± 0.063