Table 1.
Demographic, Clinical, and Serologic Characteristics of ANCA-IIP and IIP
| Characteristic | ANCA-IIP (n = 61) | IIP(n = 286) | P -value |
|---|---|---|---|
| Age, y | 60.00 (50.00,68.00) | 58.50 (50.00,66.00) | 0.328 |
| Sex, male | 29 (47.5) | 156 (54.5) | 0.319 |
| Former or current smoker | 10 (16.4) | 100 (35.0) | 0.005 |
| Follow-up time, months | 64.00 (43.00,83.50) | 62.50 (37.75,87.00) | 0.923 |
| Symptoms | |||
| Fever | 14 (23.0) | 78 (27.3) | 0.488 |
| Cough | 46 (75.4) | 215 (75.2) | 0.969 |
| Fatigue | 8 (13.1) | 44 (15.4) | 0.652 |
| Arthralgia | 12 (19.7) | 22 (7.7) | 0.004 |
| Signs | |||
| Rash | 7 (11.5) | 19 (6.6) | 0.188 |
| Mechanics hand | 5 (8.2) | 9 (3.1) | 0.079 |
| Gottron’s sign | 3 (4.9) | 12 (4.2) | 0.734 |
| Laboratory findings | |||
| WBC,109/L | 6.68 (5.90,9.04) | 7.33 (6.01,9.21) | 0.516 |
| NE,109/L | 4.54 (3.40,6.43) | 4.61 (3.55,6.18) | 0.780 |
| PLT,109/L | 237.00 (175.50,287.00) | 225.00 (185.50,295.25) | 0.976 |
| ESR, mm/h | 19.00 (8.00,44.00) | 16.00 (8.00,37.25) | 0.397 |
| Hs-CRP, mg/dL | 2.22 (0.85,7.87) | 3.85 (1.23,11.91) | 0.085 |
| ANCA | |||
| c-ANCA | 9 (14.8) | - | - |
| p-ANCA | 47 (77.0) | - | - |
| MPO-ANCA | 25 (41.0) | - | - |
| PR3-ANCA | 8 (13.1) | - | - |
| anti-CCP positive | 1 (1.6) | 4 (1.4) | 1.000 |
| RF positive | 10 (16.4) | 27 (9.4) | 0.080 |
Data are presented as the medians (IQRs), means ± SDs or No. (%)
ANCA anti-neutrophil cytoplasmic antibody, IIP idiopathic interstitial pneumonia, WBC white blood cell, PLT platelet, ESR erythrocyte sedimentation rate, Hs-CRP hypersensitivity-C reactive protein, MPO myeloperoxidase, PR3 proteinase 3, anti-CCP anti-cyclic citrullinated peptide antibody, RF rheumatoid factor