Table 3.
Comparision of Clinical Characteristics MPO-ANCA-IIP and non-MPO-ANCA-IIP
| Characteristic | MPO-ANCA-IIP(n = 25) | Non-MPO-ANCA-IIP(n = 36) | P -value |
|---|---|---|---|
| Age, y | 64.00 (46.00,70.50) | 60.00 (53.25,64.00) | 0.533 |
| Sex, male | 13 (52.0) | 16 (44.4) | 0.561 |
| Former or current smoker | 5 (20.0) | 5 (13.9) | 0.526 |
| Follow-up time, months | 62.00 (29.00,83.00) | 65.50 (49.00,85.75) | 0.486 |
| Symptoms | |||
| Fever | 6 (24.0) | 8 (22.2) | 0.871 |
| Cough | 15 (60.0) | 31 (86.1) | 0.020 |
| Fatigue | 3 (12.0) | 5 (13.9) | 1.000 |
| Arthralgia | 5 (20.0) | 7 (19.4) | 1.000 |
| Signs | |||
| Rash | 3 (12.0) | 4 (11.1) | 1.000 |
| Mechanics hand | 0 | 5 (13.9) | 0.072 |
| Gottron’s sign | 0 | 3 (8.3) | 0.262 |
| Laboratory findings | |||
| WBC,109/L | 7.20 (5.65,9.01) | 6.65 (5.94,9.09) | 1.000 |
| NE,109/L | 4.71 (3.22,6.10) | 4.51 (3.42,6.93) | 0.747 |
| PLT,109/L | 226.00 (173.50,277.50) | 252.50 (178.25,290.50) | 0.472 |
| ESR, mm/h | 16.50 (8.00,58.50) | 20.50 (8.00,42.25) | 0.780 |
| Hs-CRP, mg/dL | 3.79 (0.64,13.09) | 1.98 (0.99,4.14) | 0.342 |
| ANCA | |||
| c-ANCA | 0 | 9 (22.0) | - |
| p-ANCA | 23 (92.0) | 24 (66.7) | - |
| MPO-ANCA | 25 (100) | 0 | - |
| PR3-ANCA | 3 (12.0) | 5 (13.9) | - |
| anti-CCP positive | 1 (4.0) | 0 | 0.400 |
| RF positive | 3 (12.0) | 7 (19.4) | 0.727 |
Data are presented as the medians (IQRs), means ± SDs or No. (%)
ANCA anti-neutrophil cytoplasmic antibody, IIP idiopathic interstitial pneumonia, WBC white blood cell, PLT platelet, ESR erythrocyte sedimentation rate, Hs-CRP hypersensitivity-C reactive protein, MPO myeloperoxidase, PR3 proteinase 3, anti-CCP anti-cyclic citrullinated peptide antibody, RF rheumatoid factor