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. 2025 May 30;23:318. doi: 10.1186/s12916-025-04142-7

Table 2.

Univariable and multivariable linear regression analyses of the relationship between LV trabeculation and clinical parameters

Variants Univariable linear regression Multivariable linear regression
Unadjusted β value (95% CI) Unadjusted P-value Adjusted β value (95% CI) Adjusted P-value
Age  − 0.002 (− 0.007–0.002) 0.324
Sex (female vs. male) 0.172 (0.031–0.313) 0.017 0.197 (0.053–0.340) 0.007
Syncope  − 0.002 (− 0.204–0.200) 0.984
NYHA greater than I  − 0.070 (− 0.212–0.072) 0.332
Atrial fibrillation  − 0.112 (− 0.287–0.063) 0.208
NSVT  − 0.169 (− 0.402–0.064) 0.155
Coronary artery disease 0.100 (− 0.123–0.323) 0.378
Valvular heart disease 0.069 (− 0.261–0.399) 0.682
Carotid artery disease 0.061(− 0.366–0.245) 0.697
Chronic kidney disease 0.048 (− 0.534–0.631) 0.871
Stroke history 0.079 (− 0.580–0.422) 0.757
Septal reduction therapy  − 0.004 (− 0.141–0.134) 0.958
Family history of SCD 0.246 (0.030–0.461) 0.025 0.172 (− 0.043–0.386) 0.117
LVWT  − 0.005 (− 0.017–0.007) 0.456
LVEDD 0.001 (−0.001–0.012) 0.920
LVEDVi 0.002 (− 0.001–0.005) 0.163
LVEF < 50% 0.891 (0.416–1.365)  < 0.001 0.515 (0.013–1.016) 0.044
LAD  − 0.002 (− 0.012–0.007) 0.630
LVOTG  − 0.002 (− 0.004 to − 4.210e-4) 0.014  − 0.002 (− 0.004 to − 1.600e-4) 0.032
LV apical aneurysm 0.150 (− 0.479–0.778) 0.640
Extensive LGE 0.434 (0.207–0.662)  < 0.001 0.327 (0.089–0.565) 0.007

HCM hypertrophic cardiomyopathy, LAD left atrial diameter, LGE late gadolinium enhancement, extensive LGE defined as LGE extent ≥ 15%, LV left ventricular, LVEDD, LV end-diastolic diameter, LVEDVi LV end-diastolic volume index, LVEF LV ejection fraction, LVOTG LV outflow tract (LVOT) gradient, LVWT maximal left ventricular (LV) wall thickness, NSVT non-sustained ventricular tachycardia, NYHA New York Heart Association, SCD sudden cardiac death