Table 4.

Associations between LV regional trabeculation and outcomes in patients with HCM

Variants	MACEs		HF		Thromboembolic events		Ventricular arrhythmias
	Adjusted HR (95% CI)	Adjusted P-value	Adjusted HR (95% CI)	Adjusted P-value	Adjusted HR (95% CI)	P-value	Adjusted HR (95% CI)	Adjusted P-value
Extent of LV trabeculation, regional analysis
Base	1.134 (0.943–1.363)	0.182	1.193 (0.857–1.662)	0.296	1.194 (0.726–1.964)	0.484	1.167 (0.860–1.583)	0.321
Midventricular area	1.103 (0.865–1.406)	0.430	1.010 (0.551–1.854)	0.973	0.903 (0.649–1.257)	0.546	1.633 (1.155–2.309)	0.006
Apical area	1.221 (1.072–1.391)	0.003	1.381 (1.114–1.711)	0.003	1.240 (1.004–1.531)	0.046	1.213 (0.965–1.526)	0.098
Septum	1.192 (0.947–1.502)	0.135	1.381 (0.927–2.059)	0.113	1.181 (0.766–1.821)	0.451	1.388 (1.019–1.890)	0.037
Anterior free wall	1.107 (0.917–1.337)	0.289	1.415 (1.072–1.868)	0.014	1.213 (0.859–1.713)	0.274	1.119 (0.854–1.466)	0.416
Inferior free wall	1.271 (1.103–1.465)	< 0.001	1.340 (1.064–1.687)	0.013	1.383 (1.096–1.746)	0.006	1.188 (0.884–1.596)	0.253
Lateral free wall	1.123 (0.959–1.314)	0.151	1.218 (0.883–1.681)	0.230	0.979 (0.772–1.241)	0.860	1.208 (0.946–1.542)	0.130

Models were adjusted for age, sex, New York Heart Association functional class, syncope, atrial fibrillation, non-sustained ventricular tachycardia, coronary artery disease, valvular heart disease, carotid artery disease, chronic kidney disease, history of stroke, family history of sudden cardiac death, treatment strategies (septal reduction therapy or medical therapy alone), maximal left ventricular (LV) wall thickness, left ventricular ejection fraction, left atrial diameter, LV end-diastolic diameter, LV end-diastolic volume index, LV outflow tract gradient, LV apical aneurysm and late gadolinium enhancement extent