Table 3.
Outcomes
| Parameter [median (IQR)/%] | Before matching | After matching | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Total(203) | LAC(108) | CAC(95) | P | Total(86) | LAC(43) | CAC(43) | P | ||
| Primary outcome | |||||||||
| Thrombotic Complications | 51(25.1) | 27(25.2) | 24(25.3) | 1.000 | 24(27.9) | 13(30.2) | 11(25.3) | 0.810 | |
| Ischemic stroke | 26(12.8) | 11 (10.2) | 15(15.8) | 0.226 | 14(16.3) | 7(16.3) | 7(16.3) | 0.614 | |
| Arterial thrombosis | 16(7.9) | 9(8.3) | 7(7.4) | 0.799 | 8(9.3) | 5(11.6) | 3(7.0) | 0.356 | |
| Secondary outcomes | |||||||||
| Platelet (U) | 2.0(0.0,4.0) | 1.0(0.0,3.0) | 2.0(1.0,5.0) | 0.003 | 2.0(0.8,4.0) | 2.0(0.0,3.0) | 2.0(1.0,5.0) | 0.260 | |
| RBC (U) | 8.0(4.0,14.0) | 8.0(4.0,14.0) | 10.0(6.0,15.0) | 0.017 | 8.0(5.0,14.0) | 8.0(4.0,14.0) | 10.0(6.0,15.5) | 0.115 | |
| FFP (ml) | 400(0,800) | 400(0,800) | 600(400,1000) | 0.001 | 400(200,800) | 400(0,800) | 400(200,1000) | 0.820 | |
| VA-ECMO duration (hours) | 141.8(95.2,202.0) | 123.2(89.4,177.5) | 159.0(119.4,215.3) | 0.001 | 137.7(90.3,203.4) | 119.6(81.7,149.5) | 146.0(111.0,215.0) | 0.015 | |
| Mechanical ventilation time (hours) | 180.3(96.6,269.8) | 154.0(87.8,267.4) | 207.3(101.7,284.5) | 0.053 | 190.0(99.9,270.5) | 169.8(103.8,270.4) | 207.3(98.3,270.8) | 0.607 | |
| Hospital-stay (days) | 22.0(16.0,30.0) | 22.0(16.0,30.0) | 23.0(17.0,31.0) | 0.739 | 21.0(14.8,28.0) | 22.0(16.0,30.5) | 23.0(15.0,31.0) | 0.156 | |
| Time3 | 0.7(0.4,0.8) | 0.7(0.4,0.8) | 0.6(0.3,0.9) | 0.521 | 0.6(0.5,0.8) | 0.6(0.4,0.8) | 0.7(0.5,0.9) | 0.143 | |
| Pulmonary infection | 177(87.2) | 93 (86.1) | 84 (88.4) | 0.779 | 79(91.9) | 36(83.7) | 37(86.0) | 0.738 | |
| Bleeding Complications | 35 (17.2) | 17 (15.7) | 18 (18.9) | 0.676 | 14(16.3) | 5(11.6) | 9(20.9) | 0.382 | |
| Cannulation site bleeding | 11(5.4) | 4(3.7) | 7(7.4) | 0.354 | 3(3.5) | 2(4.7) | 1(2.3) | 0.500 | |
| Intracranial hemorrhage | 10(4.9) | 5(4.6) | 5(5.3) | 0.835 | 5(5.8) | 4(9.3) | 1(2.3) | 0.180 | |
| RRT | 113(55.7) | 52(48.1) | 61(64.2) | 0.022 | 48(55.8) | 22(51.2) | 26(60.5) | 0.515 | |
| In-hospital mortality | 97 (47.8) | 51 (47.2) | 46 (48.4) | 0.976 | 47(54.7) | 28(65.1) | 19(44.2) | 0.083 | |
LAC low anticoagulation strategy, CAC conventional anticoagulation strategy, IQR interquartile range, RBC red blood cells, FFP fresh frozen plasma, VA-ECMO. Veno-arterial extracorporeal membrane oxygenation, Time1 = time to start anticoagulation - time to start ECMO; Time2 = time to end anticoagulation - time to start anticoagulation; Time3 = Time2/ECMO duration, RRT renal replacement therapy