Table 2.
Baseline characteristics of PH patients with pregnancy based on altitude of residence
| Variable | Total (N = 52) | Group 1 (N = 11) | Group 2 (N = 26) | Group 3 (N = 15) | P value |
|---|---|---|---|---|---|
| Age (y) | 31.46 ± 5.75 | 30.45 ± 5.87 | 32.27 ± 6.10 | 30.80 ± 5.17 | 0.601 |
| Altitude of Residence, m | 1791.42 ± 270.17 | 1411.55 ± 135.53 | 1799.81 ± 155.43 | 2055.47 ± 146.38 | 0.000 |
| mPASP, mmHg | 57.83 ± 21.85 | 60.91 ± 26.74 | 60.73 ± 22.33 | 50.53 ± 16.07 | 0.315 |
| Elderly Pregnant Women | 18 (34.6) | 3 (27.3) | 10 (38.5) | 5 (33.3) | 0.927 |
| PASP | |||||
| <50 | 22 (42.3) | 5 (45.5) | 9 (34.6) | 8 (53.3) | 0.504 |
| 50–79 | 20 (38.5) | 3 (27.3) | 11 (42.3) | 6 (40.0) | 0.701 |
| ≥80 | 10 (19.2) | 3 (27.3) | 6 (23.1) | 1 (6.7) | 0.000 |
| CHD | 17 (29.3) | 5 (45.5) | 7 (26.9) | 5 (30.0) | 0.5460 |
| Delivery, median weeks of pregnancy (Q1–Q3) | 35 (31.0–38.0) | 34 (28.0–36.3) | 35 (31.5–38.5) | 35 (30.0–38.0) | 0.295 |
| Cesarean Section | 41 (78.8) | 8 (72.7) | 21 (80.8) | 12 (80.0) | 0.001 |
| Vaginal delivery | 1 (1.9) | 0 (0) | 1 (3.8) | 0 (0) | 0.000 |
| Medicine | |||||
| PH Targeted Therapy | 7 (13.5) | 0 (0) | 6 (23.1) | 1 (6.7) | 0.000 |
| Diuretic | 20 (38.5) | 5 (45.5) | 10 (38.5) | 5 (33.3) | 0.215 |
| Anticoagulants | 27 (51.9) | 2 (18.2) | 18 (69.2) | 7 (46.7) | 0.017 |
| Cardiotonic | 5 (9.6) | 1 (9.1) | 4 (15.4) | 0 (0) | 0.000 |
| CCB | 4 (7.7) | 2 (18.2) | 1 (3.8) | 2 (13.3) | 0.000 |
| General Anesthesia | 11 (21.2) | 1 (9.1) | 8 (30.8) | 2 (13.3) | 0.000 |
| Transfusion | 10 (19.2) | 1 (9.1) | 5 (19.2) | 4 (26.7) | 0.000 |
| Tracheal Intubation | 10 (19.2) | 1 (9.1) | 8 (30.8) | 1 (6.7) | 0.000 |
| Comorbidity | |||||
| Diabetes | 12 (21.2) | 2 (18.2) | 8 (30.8) | 2 (13.3) | 0.000 |
| Hypertension | 4 (7.7) | 0 (0) | 3 (11.5) | 1 (6.7) | 0.000 |
| Preeclampsia | 8 (15.4) | 2 (18.2) | 3 (11.5) | 3 (20.0) | 0.000 |
| Hypothyroidism | 5 (9.6) | 0 (0) | 3 (11.5) | 2 (13.3) | 0.000 |
| Maternal adverse events | |||||
| Postpartum hemorrhage | 6 (11.5) | 0 (0) | 3 (11.5) | 3 (20.0) | 0.000 |
| Pneumonia | 6 (11.5) | 1 (9.1) | 4 (15.4) | 1 (6.7) | 0.000 |
| Heart Failure | 12 (23.1) | 3 (27.3) | 7 (26.9) | 2 (13.3) | 0.000 |
| VTE/PE | 2 (3.8) | 0 (0) | 2 (7.7) | 0 (0) | 0.000 |
| Respiratory Failure | 2 (3.8) | 2 (18.2) | 0 (0) | 0 (0) | 0.000 |
| Hospital stays, d | 9.81 ± 5.14 | 8.36 ± 2.16 | 11.15 ± 6.73 | 8.53 ± 2.33 | 0.442 |
| Hospitalization costs (CYN) | 19759.72 ± 18559.37 | 12289.18 ± 6343.36 | 25572.04 ± 24101.36 | 15938.4 ± 10253.28 | 0.119 |
G1: ≤ 1500 m; G2: 1501–1999 m; G3: ≥ 2000 m; PASP: pulmonary arterial systolic pressure; CCB: Calcium Channel Blocker; PE: pulmonary embolism; VTE: venous thromboembolism; CNY: Chinese Yuan