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. 2025 May 27;13:e19440. doi: 10.7717/peerj.19440

Table 1. Advantages and disadvantages of KGF-2 expression by different expression systems.

Expression system Advantages Disadvantages
Bacteria Easy to manipulate Poor folding capacity
Low cost Endotoxin accumulation
High expression Lack of post-translational modifications
Short turnaround time
Ease of scale up
Yeast Easy to manipulate The thick and hard cell walls
High expression Medium turnaround time
Rapid growth and scalable Low endotoxin content
Simple culture conditions Hyperglycosylation of proteins
With post-translational modifications Limited glycosylation capacity
Plant Low cost Low expression
Optimized growth conditions Long turnaround time
Free from pathogen contaminants Limited glycosylation capacity
Free from bacterial toxin contaminants
With post-translational modifications
The oil body fusion strategy was used