Bacteria |
Easy to manipulate |
Poor folding capacity |
|
Low cost |
Endotoxin accumulation |
|
High expression |
Lack of post-translational modifications |
|
Short turnaround time |
|
|
Ease of scale up |
|
Yeast |
Easy to manipulate |
The thick and hard cell walls |
|
High expression |
Medium turnaround time |
|
Rapid growth and scalable |
Low endotoxin content |
|
Simple culture conditions |
Hyperglycosylation of proteins |
|
With post-translational modifications |
Limited glycosylation capacity |
Plant |
Low cost |
Low expression |
|
Optimized growth conditions |
Long turnaround time |
|
Free from pathogen contaminants |
Limited glycosylation capacity |
|
Free from bacterial toxin contaminants |
|
|
With post-translational modifications |
|
|
The oil body fusion strategy was used |
|