Table 4.
CMR Thresholds for RV Indices Proposed in Selected Prospective Studies of TR Patients
| First Author | Year | Study Type | Patient Population |
Primary Endpoint | N | Follow-Up | RV Parameters Associated With the Primary Outcome | HR | CMR Details |
|---|---|---|---|---|---|---|---|---|---|
| Park et al | 2016 | Prospective cohort | Patients undergoing surgery for severe functional TR | 5.8 y: Cardiac death | 75 | Median 57 mo | RV EF (%):≥46 vs <46 RV ESVI (mL/m2): ≥76 vs <76 |
RV EF aHR: 0.714 (95% CI: 0.528-0.966) RV ESVI aHR: 1.183 (95% CI: 1.025-1.365) |
Steady-state free-precession |
| Hinojar et al | 2021 | Prospective cohort | Patients with significant TR | 5-y: A composite of hospital admission due to right heart failure and cardiovascular mortality | 75 | Median 3 y | eRVEF (%) ≥24 vs <24 RV strain (%) −14 (HR: 4.76) |
eRVEF: HR per 1% aHR: 0.91 (0.87-0.95) RV strain per 1% aHR: 1.24 (95% CI: 1.11-1.39) |
Steady-state free-precession |
| Ahn et al | 2021 | Prospective cohort | Patients who underwent TV surgery for functional TR were comprehensively reviewed | 10 y: MACE and all-cause mortality | 78 | Median 5.4 y | Systolic RVMI <22 vs ≥22.0 | RVMI: HR per increase of 5 mL/m2 = 1.75 | Steady-state free-precession |
aHR = adjusted HR; CMR = cardiac magnetic resonance; EF = ejection fraction; eRVEF = effective right ventricular ejection fraction; MACE = major adverse cardiovascular events; RV = right ventricular; RV ESVI = right ventricular end-systolic volume index; RVMI = right ventricular motion index; TR = tricuspid regurgitation; TV = tricuspid valve.