Table 1.

Clinical trials performed in terms of aging prevention.

Study title	Objective	Participants	Methodology	Outcomes	National Clinical Trial number
Micro needle versus fractional CO2 laser for skin aging treatment	Compare micro needling and fractional CO2 laser methods for administering ADMSCs secretome	30 females aged 35–59 with facial aging symptoms	Single-blind, randomized clinical trial; initial skin evaluation; treatments administered in a split-face mode; topical application of ADMSCs secretome; final evaluation after 6 weeks.	Skin condition, satisfaction, adverse events, and treatment preference are assessed.	NCT05508191
Mesenchymal stem cell-derived exosomes in skin rejuvenation	Explore the role of exosomes in skin rejuvenation	Not specified	Examination of the impact of exosomes on collagen production and oxidative stress inhibition; focus on WNT/β-catenin signaling pathway for skin regeneration.	Aim to slow down skin aging through the use of exosomes.	NCT05813379
Safety study of bone marrow derived stem cells on patients with cutaneous photo aging	Consider safety and efficacy of allogeneic BM-MSCs for skin photo damage treatment	Not specified	Phase I/II open-label study; MSCs derived from healthy donors; intravenous injection to patients with significant photo damage; assessment the safety and the efficacy.	The safety and advantages of MSCs in skin rejuvenation will be determined.	NCT01771679
Skin rejuvenation using stem cell secretome	Explore the impact of umbilical cord explants and MSC secretome on skin rejuvenation	Healthy women participants	Pilot clinical trial; secretome injections in hands, face, and neck; outcomes measured using various rating scales and histologic examination; photographs taken for assessment; SPSS software used for analysis.	Assessment of skin rejuvenation effects after 12 months.	NCT06217627