TABLE 3.
Summary of results in ferrets inoculated with H5N1 influenza viruses
| Virus | Number of animals
|
PB2 627 amino acid | Virulence in ferrets | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Clinical symptoms up to day 14 p.i.
|
Virus titer on day 3 p.i. (log10 mean EID50/ml)
|
||||||||||
| Wt lossa (%) | Lethargy (RIIb)c | Respiratoryc | Neurologicalc | Day of death (MDT) | Lungsc | Spleenc | Olfactory bulbc | Brainc | |||
| Thai16 | 16 | 3/3 (2.4) | 3/3 | 0/3 | 6, 7, 7d (6.6) | 3/3 (5.3) | 2/3 (2.0) | 3/3 (3.5) | 3/3 (2.9) | K | High |
| VN1203 | 17 | 2/2 (2.4) | 2/2 | 0/2 | 8, 8 (8.0) | 2/2 (4.5) | 2/2 (3.4) | 2/2 (5.0) | 2/2 (3.6) | K | High |
| VN1204 | 22 | 2/3 (1.8) | 2/3 | 1/3 | 8, 9,e survf (10.3) | 3/3 (3.8) | 0/3 (≤1.5) | 2/3 (3.1) | 1/3 (1.7) | E | High |
| Kan353 | 23 | 3/3 (2.2) | 2/3 | 1/3 | 5, 8,g surv (9.0) | 3/3 (6.2) | 2/3 (3.4) | 3/3 (5.0) | 3/3 (3.5) | K | High |
| HK486 | 10 | 2/2 (2.1) | 2/2 | 0/2 | Survived | 2/3 (4.7) | 1/3 (2.3) | 3/3 (4.2)h | 3/3 (4.2)h | E | High |
| SP83 | 11 | 2/3 (1.6) | 0/3 | 0/3 | Survived | 3/3 (3.7) | 0/3 (≤1.5) | 3/3 (3.9) | 1/3 (1.7) | E | Low |
| CkNCVD31 | 3 | 3/3 (1.3) | 0/3 | 0/3 | Survived | 2/3 (2.5) | 0/3 (≤1.5) | 1/3 (2.1) | 0/3 (≤1.5) | E | Low |
| CkKorea | 5 | 0/3 (1.0) | 0/3 | 0/3 | Survived | 3/3 (3.1) | 0/3 (≤1.5) | 3/3 (4.0) | 2/3 (2.5) | E | Low |
| CkIndon | 1 | 1/3 (1.1) | 0/3 | 0/3 | Survived | 1/3 (1.9) | 0/3 (≤1.5) | 0/3 (≤1.5) | 0/3 (≤1.5) | E | Low |
a
The percent mean maximum weight loss is shown.
b
Relative inactivity index.
c
No. of animals/total.
d
Euthanatized due to severity of clinical symptoms.
e
Euthanatized due to torticollis.
f
Survived the 14-day experimental period.
g
Euthanatized due to hind-limb paresis.
h
Olfactory bulb and brain tissues were processed together for this virus group only.