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. 2005 Sep;79(18):12045–12057. doi: 10.1128/JVI.79.18.12045-12057.2005

FIG. 2.

FIG. 2.

FIG. 2.

FIG. 2.

Drug susceptibility assays. (A) Determination of IC50 values. Data from three independent experiments are shown. Virus titers from drug-treated cells are shown relative to virus titer from untreated cells (set at 100%). The absolute virus titer from untreated cells was 8.2 × 105 ± 3.5 × 105 infected cells/ml of cell-free virus stock. The IC50 value for lamivudine was determined previously (24). ABC, abacavir; D4T, stavudine; ddC, zalcitabine; EFV, efavirenz; NVP, nevirapine. (B) Effects of drug combinations on virus titers. The concentrations of individual drugs used in the following experiments were chosen based on the effects of the individual drugs and combined drugs on virus infectivity. Data from three independent experiments are shown. Virus titers from drug-treated cells are shown relative to the virus titer from untreated cells (set at 100%). The absolute virus titer from untreated cells was 11.5 × 105 ± 1.6 × 105 infected cells/ml of cell-free virus stock.