TABLE 2.

Influence of zidovudine and zidovudine-resistant reverse transcriptase on HIV-1 mutant frequencies^a

Drug	RT variant	Avg relative mutation frequencyb
		luc	lacZα
None	Wild type RT	1	1
Zidovudine		2.6 ± 0.4	7.6
None	Zidovudine resistant RTc	2.2 ± 0.5	4.3
Zidovudine		6.5 ± 0.3	24

^aData represent the average of three independent experiments. The average number of relative light units detected from infected cells for virus replication in wild-type RT was 7.0 × 10² ± 45.

^bData were obtained by using the luc gene or lacZα (26) as the mutation target.

^cThe resistant RT variant contained the mutations M41L, D67N, K70R, and T215Y.