FIG. 9.

Model for how gE/gI functions in cell-to-cell spread. gE/gI and gD promote secondary envelopment of HSV into TGN/endosomal vesicles. gE/gI is sorted to specific TGN subcompartments that ultimately lead to sorting to lateral cell junctions (denoted B). Other TGN subcompartments contain proteins that are sorted to apical surfaces (denoted A). Virions that reach cell junctions move into the narrow spaces between cells and interact with gD (nectin-1) and gE/gI receptors that promote HSV entry into adjacent cells.