FIG. 2.

Increased KLRG1 expression by LCMV-specific memory CD8 T cells from CD40-deficient mice. B6 (open circles) and B6.CD40^−/− (closed circles) mice (obtained from the Jackson Laboratory, Bar Harbor, ME) were infected with LCMV, and at the indicated times after infection, PBLs were stained with D^b/LCMV GP_33-41 or D^b/LCMV NP_396-404 tetramers and with monoclonal antibodies specific for CD8 and KLRG1. In panels A and C, percent GP_33-41 tetramer⁺ (A) and NP_396-404 tetramer⁺ (C) cells of CD8 T cells from individual mice are shown. In panels B and D, percent KLRG1⁺ cells of GP_33-41 (B) and of NP_396-404 (D) tetramer⁺ cells from the same mice are depicted. Data are derived from three individual mice (indicated by lines) per group that were analyzed at weeks 1 and 18 after LCMV infection, and relevant P values are indicated.