Table 3.
Stroke-related factors associated with borderline case of anxiety (8 ≤ HADS_A ≤ 10) and post-stroke anxiety (PSA) (HADS_A ≥ 11) at 3, 6, and 12 months using multinomial logistic regression analysis
| Stroke-related factors |
3 months post-stroke |
6 months post-stroke |
12 months post-stroke |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Borderline case | PSA | Borderline case | PSA | Borderline case | PSA | |||||||
| p-value | UOR [95% CI] | p-value | UOR [95% CI] | p-value | UOR [95% CI] | p-value | UOR [95% CI] | p-value | UOR [95% CI] | p-value | UOR [95% CI] | |
| Duration of hospital stay | 0.338 | 1.042 [0.958—1.134] | 0.007 | 1.099 [1.026—1.176] | 0.152 | 1.057 [0.980—1.140] | 0.010 | 1.089 [1.021—1.162] | 0.177 | 1.052 [0.977—1.131] | 0.025 | 1.072 [1.009—1.140] |
| NIHSS at 3 months | < 0.001 | 1.170 [1.082—1.265] | < 0.001 | 1.207 [1.122—1.298] | < 0.001 | 1.145 [1.063—1.234] | < 0.001 | 1.193 [1.113—1.279] | 0.004 | 1.113 [1.035—1.196] | < 0.001 | 1.169 [1.094—1.249] |
| NIHSS at 6 months | 0.003 | 1.136 [1.044—1.235] | < 0.001 | 1.198 [1.109—1.294] | 0.003 | 1.134 [1.043—1.233] | < 0.001 | 1.198 [1.110—1.294] | ||||
| NIHSS at 12 months | 0.009 | 1.141 [1.034—1.259] | < 0.001 | 1.2 [1.099—1.312] | ||||||||
| mRS at 3 months | 0.030 | 1.520 [1.041—2.218] | < 0.001 | 2.541 [1.693—3.549] | 0.138 | 1.330 [0.912—1.939] | < 0.001 | 2.413 [1.650—3.527] | 0.007 | 1.847 [1.179—2.892] | < 0.001 | 2.689 [1.725—4.192] |
| mRS at 6 months | 0.161 | 1.307 [0.899—1.899] | < 0.001 | 2.036 [1.458—2.844] | 0.003 | 1.976 [1.268—3.079] | < 0.001 | 2.539 [1.681—3.835] | ||||
| mRS at 12 months | 0.001 | 2.196 [1.406—3.430] | < 0.001 | 2.817 [1.851—4.286] | ||||||||
| SF12 of QoL | ||||||||||||
| PCS at 3 months | 0.454 | 0.975 [0.913—1.042] | 0.005 | 0.908 [0.850—0.971] | 0.502 | 0.977 [0.914—1.045] | 0.002 | 0.893 [0.830—0.961] | 0.049 | 0.909 [0.827—0.999] | 0.006 | 0.888 [0.816—0.966] |
| MCS at 3 months | 0.978 | 1.001 [0.948—1.056] | 0.005 | 0.935 [0.892—0.979] | 0.188 | 1.039 [0.981—1.101] | 0.014 | 0.942 [0.897—0.988] | 0.144 | 0.955 [0.898—1.016] | 0.010 | 0.932 [0.884—0.983] |
| PCS at 6 months | 0.813 | 0.994 [0.941—1.048] | < 0.001 | 0.899 [0.848—0.953] | 0.028 | 0.923 [0.860—0.991] | < 0.001 | 0.881 [0.822—0.945] | ||||
| MCS at 6 months | 0.164 | 1.037 [0.985—1.091] | 0.001 | 0.924 [0.882—0.968] | 0.033 | 0.939 [0.886—0.995] | 0.002 | 0.922 [0.877—0.970] | ||||
| PCS at 12 months | 0.001 | 0.895 [0.840—0.953] | < 0.001 | 0.885 [0.835—0.937] | ||||||||
| MCS at 12 months | < 0.001 | 0.905 [0.858—0.955] | < 0.001 | 0.892 [0.848—0.937] | ||||||||
Bold numbers represent significant association with p-value ≤ 0.05
HADS_A Hospital Anxiety and Depression Scale_ Anxiety score, PSA Post-stroke Anxiety, UOR Unadjusted Odds Ratio, CI Confidence Interval, NIHSS National Institutes of Health Stroke Scale, mRS modified Rankin Scale, SF12 of QoL Short Form Health Survey of Quality of Life, PCS physical component summary, MCS mental component summary