Table 4. GRADE assessment of certainly and quality of the evidence .
| Certainty assessment | No of patients | Effect | Certainty | ||||||||
| No. of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Novamin | [comparison] |
Relative
(95% CI) |
Absolute
(95% CI) |
|
| Remineralization | |||||||||||
| 3 | Randomized trials | Serious | Not serious | not serious | not serious | none | 73 | 73 | - | SMD 0.29 SD lower (0.64 lower to 0.05 higher) | ⨁⨁⨁◯ Moderate |
| Lesion depth | |||||||||||
| 3 | In vitro studies | Serious | Serious | not serious | not serious | none | 45 | 42 | - | MD 63.98 micrometer lower (92.26 lower to 35.71 lower) | ⨁◯◯◯ Very low |