| Dermatological |
Skin thickening, seborrhoea, acne, lipomas, acanthosis nigricans, leuko-melanoderma, scleroderma-like syndrome |
| Endocrine and metabolic |
Dyslipidemia (hypertriglyceridemia and low high-density lipoprotein), dysglycemia (glucose intolerance, impaired fasting glucose, or diabetes mellitus [DM]), polycystic ovary syndrome (hyperandrogenism, oligomenorrhea, infertility), hyperphagia |
| Cardiovascular |
Systemic arterial hypertension (SAH), silent myocardial ischaemia, dilated cardiomyopathy, and arrhythmias |
| Gastrointestinal |
MASLD with potential progression to cirrhosis, acute pancreatitis due to hypertriglyceridemia |
| Genitourinary |
Chronic kidney disease (secondary to DM and SAH), nephropathy with proteinuria |
| Neurological |
Diabetic or laminopathy-related neuropathy, cerebrovascular disease |
| Musculoskeletal |
Muscle hypertrophy or pseudohypertrophy, myalgia or myopathy (FPLD2), chronic and diffuse pain |
| Psychiatric |
Depression, anxiety, and impaired quality of life |
