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. 2025 May 19;16:1580271. doi: 10.3389/fmicb.2025.1580271

Figure 4.

Figure 4

Comparison of the genetic organization of cpe-positive plasmids between CP280 and type F strains. The nucleotide sequences of 19 cpe-positive plasmids of type F strains were downloaded from the NCBI database, and the genetic organization of the plasmids was compared with that of pCP280-55k from strain CP280 using clinker under CAGECAT. The arrows and arrowheads represent genes. cpe is indicated by black arrows. Genes with 50% or more nucleotide sequence identity are connected to each other by colored bands. The 20 plasmids were classified into six groups (I–VI) based on their genetic organization, plasmid length, and types of transposase genes flanking the cpe gene. pCP280-55k was the only member of group I, while the other 19 plasmids were classified in groups II–VI (seven in group II, three in group III, six in group IV, two in group V, and one in group VI). This figure shows the genetic organization of the representative plasmids in each group. (C) and (L) described next to the strains’ name indicate the topology “Circular” and “Linear”, respectively.